Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study

NCT07560995 | Not Yet Recruiting

• 1 other identifier: CE-2025-86
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Internuclear ophthalmoplegia is a symptom frequently associated with multiple sclerosis (MS), although other etiologies are possible. Some patients do not meet the diagnostic criteria for MS at the time of the internuclear ophthalmoplegia episode but subsequently convert to MS. Studying this specific clinical situation may help enable earlier diagnosis of MS. The objective is to analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis and to identify factors associated with this conversion. The study hypothesis is that the presence of internuclear ophthalmoplegia is highly suggestive of multiple sclerosis, particularly when cerebrospinal fluid-specific oligoclonal bands are present.

Conditions

Multiple Sclerosis; Internuclear Ophthalmoplegia

Outcome Measures

Primary Outcomes (1)

• Analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis.

  Proportion of patients with isolated internuclear ophthalmoplegia who converted to multiple sclerosis during follow-up.

  1 year

Study Arms (1)

Internuclear ophthalmoplegia

This is a retrospective cohort study involving patients who have experienced internuclear ophthalmoplegia. For each patient, it is determined whether a diagnosis of multiple sclerosis was established or not.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The extraction of records will be performed through a search using PMSI coding within the medical files of patients hospitalized in a neurology department.

You may qualify if:

• Patients with a PMSI code H51.2 (internuclear ophthalmoplegia) listed as a primary or associated diagnosis
• Patients hospitalized in a neurology department
• Adult patients

You may not qualify if:

• \- Patients under 18 years of age

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Les Hôpitaux Universitaires

Strasbourg, 67 200, France

Location

MeSH Terms

Conditions

Multiple Sclerosis; Ocular Motility Disorders

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Central Nervous System Diseases; Cranial Nerve Diseases; Eye Diseases

Study Officials

• Kévin BIGAUT

  Hôpitaux Universitaires de Strasbourg

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Kévin BIGAUT

CONTACT

+33 3 88 12 60 96; kevin.bigaut@chru-strasbourg.fr

Sebille COLIN

CONTACT

+33 3 88 11 52 17; sebille.colin@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 24, 2026
• First Posted: May 1, 2026
• Study Start: May 1, 2026
• Primary Completion: May 1, 2026
• Study Completion (Estimated): May 1, 2027
• Last Updated: May 1, 2026

Record last verified: 2026-04

Locations

FR (1)