Portal Vein Thrombosis in Liver Cirrhosis: Clinical Characteristics, Radiological Patterns, and Predictors

NCT07560202 | Active Not Recruiting

• 1 other identifier: AUN-PVT-LC-2026
• Study Type: observational
• Target: 240
• Locations: 1 country
• Sites: 1

Brief Summary

Portal vein thrombosis (PVT) is a common complication in patients with liver cirrhosis and is associated with increased morbidity due to worsening portal hypertension and hepatic decompensation. The clinical presentation and radiological patterns of PVT vary widely, and the factors predicting its development remain incompletely understood. This observational study will include adult patients (≥18 years) with established liver cirrhosis who are admitted to the Department of Gastroenterology and Tropical Medicine, Al-Rajhi Liver Hospital, Assiut University. Eligible participants will undergo routine screening for PVT using Doppler ultrasonography, with confirmation by contrast-enhanced computed tomography when indicated. The study aims to evaluate the clinical characteristics, laboratory parameters, and radiological features of PVT. Cases of PVT will be classified according to extent (partial or complete) and anatomical location (main portal vein, right branch, left branch, or combined involvement). Clinical and laboratory data will be analyzed to identify potential predictors associated with the development and severity of PVT. The findings of this study are expected to improve understanding of the risk factors and radiological patterns of PVT in cirrhotic patients, contributing to better risk stratification and clinical management.

Conditions

Liver Cirrhosis; Portal Vein Thrombosis

Keywords

Portal vein thrombosis; liver cirrhosis; D-dimer

Outcome Measures

Primary Outcomes (2)

• Prevalence of Portal Vein Thrombosis (PVT)

  Proportion of cirrhotic patients diagnosed with portal vein thrombosis based on Doppler ultrasonography with confirmation by contrast-enhanced CT when indicated.

  At baseline (during study enrollment period)

• Predictors of Portal Vein Thrombosis

  Identification of clinical, laboratory, and radiological factors associated with the presence of PVT in cirrhotic patients

  Baseline assessment

Secondary Outcomes (2)

• Radiological Pattern of PVT

  At time of PVT diagnosis

• Association Between PVT Type and Clinical Parameters

  At time of diagnosis

Study Arms (1)

Group 1 (Patients): with PVT, Group 2 (Controls): without PVT

Diagnostic Test: Abdominal US, Doppler US and abdominal multi-slice computed tomography (MSCT) with contrast was performed

Interventions

Abdominal US, Doppler US and abdominal multi-slice computed tomography (MSCT) with contrast was performed DIAGNOSTIC_TEST

to assess portal circulation, portosystemic collaterals, the presence of PVT, ascites and HCC.

Group 1 (Patients): with PVT, Group 2 (Controls): without PVT

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with liver cirrhosis

You may qualify if:

• Adult patients with liver cirrhosis

You may not qualify if:

• Patients with non-hepatic hemostatic disorders, active bacterial sepsis, renal dysfunction, peripheral or hepatic venous thrombosis, recent splenectomy, liver transplantation, antiplatelet or anticoagulant therapy or contraceptive pills were excluded.

Sponsors & Collaborators

• Elham Ahmed Hassan: lead

Study Sites (1)

Assiut University Hospital

Asyut, 71515, Egypt

Location

MeSH Terms

Conditions

Liver Cirrhosis

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor of Gastroenterology and Tropical Medicine

Study Record Dates

• First Submitted: April 24, 2026
• First Posted: May 1, 2026
• Study Start: June 1, 2025
• Primary Completion: January 1, 2026
• Study Completion: May 1, 2026
• Last Updated: May 1, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)