FANS VS DISS in Treatment of Renal Stone < 2cm

NCT07559214 | Not Yet Recruiting DMC

• 1 other identifier: FANS VS DISS
• Study Type: interventional
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

To compare between FANS \& DISS in :

• Operative time
• Stone free rate
• Complications
• Amount of fluid irrigation

Conditions

Renal Calculi

Outcome Measures

Primary Outcomes (1)

• Operative time

  The operative time is the duration of surgical procedure

  <60 minutes

Study Arms (2)

Flexible and navigable access sheath (FANS)

EXPERIMENTAL

In patients undergoing the FANS procedure , an access sheath with a bendable tip and aspiration feature will be placed into the relevant ureter up to the renal pelvis over the guidewire. The single-use flexible scope will be passed through the access sheath, and the renal collecting system. After this maneuver, the tip of the placed access sheath will be pushed into the renal calyces or pelvis under the guidance of the flexible URS and a holmium fiber will be used to pulverize the stones with a 273-µm fiber. In this group, stones were disintegrated (fragmented) into an adequate size (\< 3 mm) to allow an efficient extraction with the help of active aspiration, finished by insertion of JJ in all patients.

Procedure: Flexible ureteroscopy

Direct in scope suction (DISS)

EXPERIMENTAL

In the DISS group, a single-use flexible URS with a direct in-scope suction system will be introduced over the placed guidewire and navigated into the renal pelvis without the use of an access sheath. The suctioning port on the ureteroscope and the laser fiber operates via the same port. In this group, the dusting preset of the same laser device will be used to disintegrate the stones. While continuous irrigation was applied to ensure optimum visualization, finished by insertion of JJ in all patients

Procedure: Flexible ureteroscopy

Interventions

Flexible ureteroscopy PROCEDURE

Unlike traditional rigid sheaths, FANS features a deflectable tip that can be guided into specific calyces, allowing for synchronized suction and active fragment evacuation. Conversely, Direct In-Scope Suction (DISS) utilizes a sheathless approach, where suction is integrated directly into the ureteroscope. While DISS avoids potential ureteral trauma associated with access sheaths, FANS is often associated with shorter operative times due to its superior irrigation-aspiration efficiency

Also known as: FURS

Direct in scope suction (DISS); Flexible and navigable access sheath (FANS)

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• All patients \< 18 years old presented with renal stone \> 2cm whatever the site of the stone (pelvic or calyceal)

You may not qualify if:

• Inaccessibility to introduce access sheath or FURS
• Previous Inserted JJ stent
• Active UTI
• Patients refuse to participate in the protocol

Sponsors & Collaborators

• Assiut University: lead

MeSH Terms

Conditions

Kidney Calculi

Condition Hierarchy (Ancestors)

Nephrolithiasis; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Urolithiasis; Urinary Calculi; Male Urogenital Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident physician

Study Record Dates

• First Submitted: April 10, 2026
• First Posted: April 30, 2026
• Study Start (Estimated): June 1, 2026
• Primary Completion (Estimated): June 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: April 30, 2026

Record last verified: 2026-04