The Effect of Acupressure on Multiple Sclerosis Patients

NCT07558252 | Completed DMC

• 2 other identifiers: 2025/016Non
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

There are studies in the literature evaluating the effects of acupressure application in MS patients. In a study; it was shown that acupressure application reduced pain and fatigue. In a study; acupressure was found to reduce fatigue and depression scores. In a study; acupressure was found to improve the patient's physical and cognitive functions and quality of life. In a study; acupressure was found to have positive effects on reducing fatigue in MS patients. In a study acupressure application was found to have significant effects in reducing fatigue. There are no studies evaluating the combined effects of acupressure on fatigue, pain, sleep quality, and quality of life parameters in MS patients. This study is planned to determine the effects of acupressure on fatigue, pain, sleep quality, and quality of life in MS patients.

Conditions

Multiple Sclerosis

Outcome Measures

Primary Outcomes (1)

• Fatigue Severity Scale (FSS)

  The FSS is a 9-item scale used to assess the impact of fatigue on daily activities. Each item is rated on a 7-point Likert scale ranging from 1 to 7. The total score is the average of the 9 items. Scores range from 1 to 7, where higher scores indicate greater fatigue severity (worse outcome).

  Baseline, at the end of the 3rd week, and at the end of the 6th week.

Secondary Outcomes (3)

• Visual Analog Scale (VAS) for Pain

  Baseline, at the end of the 3rd week, and at the end of the 6th week.

• Pittsburgh Sleep Quality Index (PSQI)

  Baseline, at the end of the 3rd week, and at the end of the 6th week.

• Multiple Sclerosis Quality of Life-54 (MSQOL-54)

  Baseline, at the end of the 3rd week, and at the end of the 6th week.

Study Arms (3)

intervention

EXPERIMENTAL

intervention

Other: Acupressure

sham

SHAM COMPARATOR

Plasebo

Other: Acupressure

Control

NO INTERVENTION

Control

Interventions

Acupressure OTHER

examining pain, fatigue, sleep, and quality of life

intervention; sham

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• At least 6 months of confirmed MS diagnosis
• With RRMS
• Aged 18 years or older
• With a pain score of VAS≥3
• Not having used pain medication in the last 8 hours prior to the acupressure session
• With a Fatigue Severity Scale score of 4 or higher
• Without a diagnosis of cancer
• Without diabetes
• No neurological disease other than MS
• Not receiving any other complementary treatment
• Non-smoker
• Literate and able to communicate
• No deformity or lesion in the areas where acupressure will be applied
• No mental problems that could prevent cooperation with the acupressure application
• Not taking sedative medication

You may not qualify if:

• Patients who did not attend at least 4 sessions
• Patients who wish to withdraw from the study

Sponsors & Collaborators

• Hasan Kalyoncu University: lead

Study Sites (1)

Hospital of Harran University

Sanliurfa, Şanlıurfa, 63000, Turkey (Türkiye)

Location

Related Links

• Related Info

MeSH Terms

Conditions

Multiple Sclerosis

Interventions

Acupressure

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Intervention Hierarchy (Ancestors)

Therapy, Soft Tissue; Musculoskeletal Manipulations; Complementary Therapies; Therapeutics; Physical Therapy Modalities; Rehabilitation

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer

Study Record Dates

• First Submitted: April 7, 2026
• First Posted: April 30, 2026
• Study Start: March 1, 2025
• Primary Completion: November 1, 2025
• Study Completion: April 1, 2026
• Last Updated: April 30, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)