High-intensity Laser Therapy and Mulligan Mobilization for Patients With Chronic Nonspecific Low Back Pain

NCT07556926 | Not Yet Recruiting DMC

• 1 other identifier: ADAD/1199
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to evaluate whether combining high-intensity laser therapy with Mulligan mobilization techniques can effectively treat chronic non-specific low back pain in adult patients aged 18-60 years, including both males and females. The main questions it aims to answer are: Does the combined intervention reduce pain intensity more effectively than standard or single-modality treatment? Does the combined intervention improve functional disability and lumbar range of motion? Researchers will compare high-intensity laser therapy combined with Mulligan mobilization to \[control group: Mulligan alone\] to determine whether the combined approach produces superior clinical outcomes. Participants will: Receive high-intensity laser therapy according to a standardized treatment protocol Undergo Mulligan mobilization techniques administered by a trained therapist Attend multiple treatment sessions over a defined intervention period Complete assessments of pain intensity, functional disability, and lumbar range of motion before and after treatment

Conditions

Low Back Pain

Outcome Measures

Primary Outcomes (1)

• Numeric Pain Rating Scale (NPRS)

  The Numeric Pain Rating Scale (NPRS) is a self-reported measure used to assess pain intensity. It typically consists of an 11-point scale ranging from 0 to 10, where 0 indicates "no pain" and 10 represents "the worst imaginable pain." Participants are asked to select the number that best reflects their current level of pain, or their average pain over a specified period. The NPRS is widely used in clinical and research settings due to its simplicity, reliability, and validity in measuring pain intensity in individuals with musculoskeletal conditions, including chronic low back pain. Changes in NPRS scores over time are used to evaluate the effectiveness of therapeutic interventions, with a reduction of approximately 2 points often considered clinically meaningful.

  Change from baseline NPRS at 4-week

Secondary Outcomes (2)

• Oswestry Disability Index (ODI)

  Change from baseline ODI at 4-week

• Lumbar Flexion Range of Motion (ROM)

  Change from baseline Lumbar Flexion Range of Motion (ROM) at 4-week

Study Arms (2)

Mulligan Mobilization

ACTIVE COMPARATOR

Mulligan Mobilization alone

Other: Mulligan Mobilization

High-intensity laser therapy and Mulligan mobilization

EXPERIMENTAL

Combined high-intensity laser therapy and Mulligan mobilization

Device: High-intensity laser therapy and Mulligan mobilization

Interventions

High-intensity laser therapy and Mulligan mobilization DEVICE

Combined high-intensity laser therapy and Mulligan mobilization

High-intensity laser therapy and Mulligan mobilization

Mulligan Mobilization OTHER

Mulligan Mobilization alone

Mulligan Mobilization

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Male and female participants aged 18-60 years
• Diagnosis of chronic non-specific low back pain (pain persisting for ≥3 months)
• Pain localized between the lower costal margins and gluteal folds, with or without referred pain
• Baseline pain intensity of ≥3 on the Numeric Pain Rating Scale (NPRS)
• Ability to understand and follow instructions and provide informed consent
• Not currently receiving other forms of physiotherapy or structured treatment for low back pain during the study period

You may not qualify if:

• Specific spinal pathology (e.g., fracture, tumor, infection, inflammatory diseases such as ankylosing spondylitis)
• History of spinal surgery
• Neurological deficits or signs of nerve root compression (e.g., severe radiculopathy)
• Pregnancy
• Severe osteoporosis or other contraindications to manual therapy
• Contraindications to high-intensity laser therapy (e.g., malignancy in the treatment area, photosensitivity disorders)
• Current use of medications that significantly affect pain perception (e.g., high-dose opioids)
• Participation in another clinical trial within the last 3 months

Sponsors & Collaborators

• Anas Radi Hassan Alashram: lead

Study Sites (1)

Middle East University

Amman, Jordan

Location

MeSH Terms

Conditions

Low Back Pain

Condition Hierarchy (Ancestors)

Back Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Anas Radi Alashram, PhD

CONTACT

00962788088509; anasalashram@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: April 19, 2026
• First Posted: April 29, 2026
• Study Start: April 30, 2026
• Primary Completion (Estimated): May 30, 2026
• Study Completion (Estimated): June 1, 2026
• Last Updated: April 29, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

JO (1)