NCT07556874|Recruiting
Descriptive Analysis of Surgeries in Patients With Multiple Osteochondromas
CHIROS
Analisi Descrittiva di Chirurgie in Pazienti Con Osteocondromi Multipli
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CHIROS
Analisi Descrittiva di Chirurgie in Pazienti Con Osteocondromi Multipli
Sponsor study identifier
observational
300
1 country
1
Study Start
October 23, 2025
Actual (reported)Primary Completion
October 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
October 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Multiple Osteochondromas (MO), also known as Multiple Cartilaginous Exostoses, is an autosomal dominant skeletal disorder with an incidence of approximately 1 in 50,000 in Western populations. Most cases are associated with pathogenic variants in the EXT1 and EXT2 genes, which lead to a systemic reduction of heparan sulfate, causing abnormalities in bone growth and other physiological processes. Symptoms typically appear in childhood and include the development of bony protrusions often associated with pain due to compression of muscles and nerves. Patients are generally shorter than average and may experience dislocations, subluxations, reduced motor function, and skeletal deformities such as genu valgum, limb asymmetry, and scoliosis. The most severe complication is malignant transformation into chondrosarcoma, occurring in 0.5-5% of adult patients. Diagnosis is mainly based on imaging techniques (X-ray, CT, MRI, ultrasound) and is confirmed by the presence of at least two osteochondromas after excluding other conditions. Following diagnosis, patients or their caregivers often raise questions regarding disease progression, the number and type of surgical interventions required, and differences between pediatric and adult surgical approaches. This retrospective observational cohort study aims to characterize the number and types of surgical procedures performed in MO patients at a European referral center, the Rizzoli Orthopaedic Institute.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
October 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 23, 2025
Actual (reported)April 22, 2026
Actual (reported)April 29, 2026
Actual (reported)October 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
October 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Number and type of surgeries for Multiple Osteochondromas
3 years
Conceptualization of a score based on osteochondromas location (bone site), severity (grading), and deformity/limitations (number and type)
3 years
Descriptive analysis (mean, median, variance, standard deviation, interquartile range) of malignant transformations of osteochondromas
3 years
Surgeries for osteochondromas performed at the Rizzoli Orthopedic Institute
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Patients with multiple osteochondromas who underwent surgery at the Rizzoli Orthopedic Institute
IRCCS Istituto Ortopedico Rizzoli
Bologna, Bologna, 40136, Italy
First Submitted
April 22, 2026
First Posted
April 29, 2026
Study Start
October 23, 2025
Actual (reported)Primary Completion
October 2028
EstimatedThe Health-Related Quality of Life in Patients With Hereditary Multiple Exostoses
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Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
October 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
May 15, 2026
Record last verified: 2026-05
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