NCT07555821

Brief Summary

Improving postoperative analgesia after functional endoscopic surgery: Sphenopalatine ganglion block versus soaked nasal packing using bupivacaine and dexmedetomidine

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for phase_2

Timeline
6mo left

Started Apr 2026

Shorter than P25 for phase_2

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress12%
Apr 2026Oct 2026

First Submitted

Initial submission to the registry

April 14, 2026

Completed
1 day until next milestone

Study Start

First participant enrolled

April 15, 2026

Completed
14 days until next milestone

First Posted

Study publicly available on registry

April 29, 2026

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 30, 2026

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 30, 2026

Last Updated

April 29, 2026

Status Verified

April 1, 2026

Enrollment Period

7 months

First QC Date

April 14, 2026

Last Update Submit

April 21, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • effectiveness of SPGB with bupivacaine and dexmedetomidine for postoperative analgesia

    Numeric rating scale for pain will be assessed and recorded within the first 24 hours where 1 means the worst pain and 10 means no pain. Total rescue analgesia in 24 H when Numeric rating scale ≥ 4 was recorded and the first time when it was given will be recorded.

    6 months

Study Arms (2)

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EXPERIMENTAL

Sphenopalatine ganglion block (SPGB) with Bupivacaine and Dexmedetomidine

Drug: Sphenopalatine ganglion block (SPGB) with Bupivacaine and Dexmedetomidine

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EXPERIMENTAL

Sphenopalatine ganglion block (SPGB) with Bupivacaine and Dexmedetomidine

Drug: Sphenopalatine ganglion block (SPGB) with Bupivacaine and Dexmedetomidine

Interventions

Sphenopalatine ganglion block (SPGB) with Bupivacaine and Dexmedetomidine

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Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Age 18 - 60 years
  • ASA physical status I -II
  • Patients scheduled for elective FESS

You may not qualify if:

  • Allergy to drugs used
  • Coagulopathy or anticoagulant therapy
  • Severe cardiovascular, renal and hepatic disease
  • Chronic opioid use Pregnancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Assiut university hospital

Asyut, 161715, Egypt

Location

MeSH Terms

Interventions

Sphenopalatine Ganglion BlockDexmedetomidine

Intervention Hierarchy (Ancestors)

Autonomic Nerve BlockNerve BlockAnesthesia, ConductionAnesthesiaAnesthesia and AnalgesiaDenervationNeurosurgical ProceduresSurgical Procedures, OperativeImidazolesAzolesHeterocyclic Compounds, 1-RingHeterocyclic Compounds

Central Study Contacts

Sara Mansour Mansour

CONTACT

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
anesthesia consultant

Study Record Dates

First Submitted

April 14, 2026

First Posted

April 29, 2026

Study Start

April 15, 2026

Primary Completion (Estimated)

October 30, 2026

Study Completion (Estimated)

October 30, 2026

Last Updated

April 29, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations