NCT07555795

Brief Summary

The goal of this clinical trial is to evaluate whether a wearable biofeedback smartbelt system can improve pain and disability in adults with chronic lower back pain. The intervention combines a wearable belt that measures muscle activity with a mobile application that provides real-time feedback during exercise. The main questions it aims to answer are:

  • Does the MMG-biofeedback system improve disability, as measured by the Oswestry Disability Index (ODI), compared to standard care alone over an 8-week period?
  • Does the system reduce perceived pain levels and improve exercise adherence in individuals with lower back pain over an 8-week period? Researchers will compare participants receiving the MMG-biofeedback belt alongside standard care to those receiving standard care alone to determine whether the addition of real-time muscle activation feedback leads to improved outcomes. Participants will:
  • Be randomly assigned to either the intervention group (biofeedback system + standard care) or control group (standard care only)
  • Complete an 8-week home-based exercise programme, all participants are asked to complete the programme at least 5 times a week
  • Use the wearable belt and mobile application during exercise sessions (intervention group only)
  • Receive a booklet with the exercise programme and video links (control group only)
  • Complete questionnaires on pain, disability, and usability at baseline and after 8 weeks, and at a 3-month follow-up
  • Have their exercise adherence and engagement monitored throughout the study The study includes an initial pilot phase to assess feasibility, followed by a larger randomised controlled phase to evaluate early clinical effectiveness.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at P25-P50 for not_applicable

Timeline
11mo left

Started Apr 2026

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress5%
Apr 2026Apr 2027

Study Start

First participant enrolled

April 20, 2026

Completed
1 day until next milestone

First Submitted

Initial submission to the registry

April 21, 2026

Completed
8 days until next milestone

First Posted

Study publicly available on registry

April 29, 2026

Completed
12 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 20, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 20, 2027

Last Updated

April 29, 2026

Status Verified

April 1, 2026

Enrollment Period

1 year

First QC Date

April 21, 2026

Last Update Submit

April 21, 2026

Conditions

Keywords

wearablescore muscleexercise therapybiofeedback

Outcome Measures

Primary Outcomes (2)

  • Oswestry Disability Index

    From enrollment to 3 months after the end of treatment period (8 weeks treatment)

  • Pain Visual Analogue Scale

    From enrollment to 3 months after the end of treatment period (8 weeks treatment)

Secondary Outcomes (3)

  • EQ-5D-5L

    From enrollment to 3 months after the end of treatment period (8 weeks treatment)

  • MSK-HQ

    From enrollment to 3 months after the end of treatment period (8 weeks treatment)

  • Exercise Adherence

    From enrollment to the end of treatment at 8 weeks

Other Outcomes (2)

  • Qualitative user surveys

    From enrollment to the end of treatment at 8 weeks

  • Strength and Endurance

    From enrollment to the end of treatment at 8 weeks.

Study Arms (2)

Exercise with real-time muscle biofeedback

EXPERIMENTAL

Participants randomised to the intervention arm will receive a standardised lab session on the use of the MMG-biofeedback belt and mobile application. A physiotherapist or trained researcher will demonstrate how to perform each exercise, correct belt positioning, app navigation, calibration procedures, and how to interpret the real-time muscle activation feedback. Participants will be issued the MMG-biofeedback belt and app after training and will use the system throughout their prescribed home-based exercise sessions for the full eight-week intervention period. Participants are asked to perform the exercise programme (20-30 mins) at least 5 times a week. The app will provide real-time feedback on muscle activation, progress summaries and reminders. Participants are asked to carry on any other treatment as usual. Aside from routine data collection and belt troubleshooting, participants in the control group will not receive additional input from the research team.

Device: MMG-biofeedback belt

Exercise without biofeedback (waitlist control)

NO INTERVENTION

Participants randomised to the control arm will receive a standardised lab session, whereby core strength and endurance measures are taken. A physiotherapist or trained researcher will demonstrate how to perform each exercise. Participants will be issued with a booklet containing the exercise programme with exercise video links and are asked to perform their prescribed home-based exercise sessions for the full eight-week intervention period. Participants are asked to perform the exercise programme (20-30 mins) at least 5 times a week. No MMG-biofeedback belt will be provided to this group, participants are asked to carry on any other treatment as usual. Aside from routine data collection, participants in the control group will not receive additional input from the research team.

Interventions

The intervention consists of a wearable belt incorporating mechanomyography (MMG) sensors to detect muscle activity in the abdominal and lower back regions, paired with a mobile application that provides real-time visual feedback on core muscle activation during exercise. The system is designed to guide users in engaging the correct muscles, improve exercise performance, and support adherence to a prescribed exercise programme during both supervised and home-based sessions.

Also known as: UPPITT
Exercise with real-time muscle biofeedback

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Over the age of 18
  • Non-specific LBP for at least 6 weeks in the past 12 months
  • Pain 4/10 on a visual analogue scale or more or Oswestry Disability Index over 20%

You may not qualify if:

  • Serious spinal pathology ("red flags") such as:
  • History of malignancy with new onset back pain suggestive of recurrence.
  • Unexplained weight loss, fever, or systemic symptoms.
  • Recent significant trauma (e.g., fall from height, road traffic accident).
  • Suspected or confirmed spinal infection (e.g., discitis, osteomyelitis).
  • Cauda equina symptoms, including urinary retention/incontinence or saddle anaesthesia.
  • Progressive neurological deficit (e.g., worsening weakness, loss of reflexes).
  • Recent spinal surgery or invasive spinal procedures within the past 3 months.
  • Severe cardiovascular or respiratory disease that prevents safe participation in mild to moderate exercise (e.g., unstable angina, uncontrolled heart failure).
  • Pregnant women or those less than three months postpartum.
  • Known allergy to materials used in the belt (e.g., Lycra or related fabrics).
  • Cognitive impairment that prevents informed consent or ability to follow exercise instructions.
  • Concurrent participation in another intervention trial that may interfere with the study outcomes.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Imperial College London

London, United Kingdom

RECRUITING

MeSH Terms

Conditions

Low Back Pain

Condition Hierarchy (Ancestors)

Back PainPainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Paul Bentley

    Imperial College London

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Participants are allocated to either an intervention group receiving real-time muscle biofeedback via a wearable belt during exercise, or a control group performing the same exercise programme without feedback. Outcomes are assessed at baseline, after the initial study period and at a 3-month follow-up to enable comparison between groups. Following completion of the primary study phase, participants in the control group are offered access to the intervention (waitlist control design).
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 21, 2026

First Posted

April 29, 2026

Study Start

April 20, 2026

Primary Completion (Estimated)

April 20, 2027

Study Completion (Estimated)

April 20, 2027

Last Updated

April 29, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

De-identified individual participant data (IPD) underlying the results reported in publications will be made available to other researchers upon reasonable request. This will include participant-level data for primary and secondary outcomes (e.g. disability scores, pain scores, adherence metrics), along with relevant baseline characteristics. Raw sensor data (e.g. MMG signals) and proprietary algorithms will not be shared in full due to intellectual property considerations. However, processed or aggregated data derived from these signals may be shared where appropriate to support reproducibility of findings. All shared data will be fully anonymised in accordance with GDPR and institutional data protection policies.

Shared Documents
STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
Time Frame
De-identified individual participant data (IPD) and supporting documents will be made available following publication of the primary study results. Data will be accessible for up to 5 years after publication. Supporting documents, including the study protocol and statistical analysis plan, may be made available earlier where appropriate.
Access Criteria
Access to de-identified IPD and supporting information will be granted to qualified researchers who provide a methodologically sound research proposal. Requests will be reviewed by the study team and subject to approval. Data will be shared under a data sharing agreement to ensure appropriate use and protection of participant confidentiality. Data will be provided in a secure, anonymised format. Proprietary data, including raw sensor signals and algorithms, will not be shared; however, processed or aggregated data sufficient to reproduce study findings may be made available upon request.

Locations