Central Sensitization, Work-Related Stress, and Musculoskeletal Symptoms in Desk-Based Workers With and Without Migraine

NCT07554664 | Not Yet Recruiting

• 1 other identifier: Approval No: 3/10; 02.04.2026
• Study Type: observational
• Target: 159
• Locations: 0 countries
• Sites: N/A

Brief Summary

Migraine is a common neurological disease causing significant disability worldwide, with an estimated global prevalence of 14.4%. It represents a significant individual and societal burden, particularly for working-age individuals, as it can significantly impact work performance, productivity, and daily living activities. Migraine is not merely a headache; it is characterized by increased excitability of neurons in the central nervous system, leading to hypersensitivity to pain. Central sensory mechanisms are thought to play a role in the pathophysiology and chronicity of migraine, causing increased pain sensitivity, allodynia, and potentially related to musculoskeletal pain. Furthermore, psychosocial factors and work stress have been identified as significant factors associated with both headaches and musculoskeletal pain. Literature indicates that neck pain is common in individuals with migraine headaches; in fact, neck pain is twice as frequent in patients with chronic migraine headaches compared to those with episodic migraine. While evidence regarding back pain is limited, it has been shown that individuals with chronic headaches report back pain more frequently. In modern work environments, sedentary work and prolonged computer use are increasing. Prolonged sitting, improper ergonomics, and repetitive movements are considered significant risk factors for musculoskeletal problems. This can lead to pain and functional limitations, particularly in the neck, shoulders, and back. Although there has been an increase in working from home, especially after the pandemic, the time spent at a desk is still similar to that spent in the workplace. It is stated that static muscle activity and improper postures maintained during prolonged computer use can lead to increased strain on cervical and upper extremity muscles, exacerbating musculoskeletal symptoms. Literature reports that headaches and neck pain are common among individuals who work at desks; for example, a study of office workers reported that approximately 80% of individuals with headaches also experienced neck pain. Furthermore, high workload, time pressure, and psychosocial stress factors have been shown to be associated with both headaches and musculoskeletal pain in individuals who work at desks. Therefore, desk-based work conditions are considered a significant environmental factor that may play a role in the onset or exacerbation of migraine and musculoskeletal symptoms. Despite this, studies examining musculoskeletal symptoms, central sensitivity, and work stress together in desk-bound migraine patients are limited in the literature. Most studies have only examined individuals with headaches or evaluated musculoskeletal findings in limited areas. Therefore, studies comparing desk-bound migraine patients with non-migraine-bound desk-bound individuals could fill a significant gap in the literature. In this context, it is believed that the planned study will contribute to a better understanding of the possible relationships between migraine and musculoskeletal symptoms, help develop protective and rehabilitative approaches to the work environment, and benefit individuals exposed to musculoskeletal risks in desk-bound work, within the scope of Sustainable Development Goals 3: ensure healthy lives and promote well-being for all at all ages. The aim of this study is to compare central sensitization, work-related stress levels, and musculoskeletal symptoms in desk-based workers according to the presence of migraine and to examine the relationships among these variables.

Conditions

Migraine; Worker Health; Sensitization; Musculoskeletal Pain; Work Stress

Keywords

Migraine Disorders; Workplace; Musculoskeletal Pain; Rehabilitation; Sensitization; Worker Health; Sustainable Development Goals; Disability; SDG 3

Outcome Measures

Primary Outcomes (1)

• Central Sensitization Inventory

  The Central Sensitization Inventory (CSI) measures somatic and emotional symptoms common in central sensitization syndrome. Section A measures 25 symptoms with 5 response options (0 to 4). The total score ranges from 0 to 100. Section B asks patients whether they have previously been diagnosed with preliminary specific CSI conditions

  Day 1

Secondary Outcomes (6)

• Headache Intensity

  Day 1

• Disability

  Day 1

• Work-Related Stress

  Day 1

• Musculoskeletal Pain Symptoms

  Day 1

• Headache Impact

  Day 1

Study Arms (3)

Episodic migraine

Episodic migraine is a neurological condition characterized by recurrent, moderate-to-severe headaches occurring on fewer than 15 days per month. Attacks typically last 4 to 72 hours and are often accompanied by nausea, vomiting, and light/sound sensitivity. Treatment involves acute, on-demand medication and preventative strategies to reduce attack frequency.

Chronic migraine

Chronic migraine is defined by having 15 or more headache days per month for over three months, with at least eight of those days meeting migraine criteria. Symptoms include moderate-to-severe throbbing pain, nausea, vomiting, and extreme sensitivity to light, sound, or smell.

Control group without migraine diagnosis

Individuals without a diagnosis of episodic or chronic migraine, as well as individuals without other headache diagnoses.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Gaziantep City Hospital, Department of Neurology, Gaziantep, Türkiye.

You may qualify if:

• Being between 18 and 65 years of age
• Having been employed in an office job for at least 6 months
• Working at a desk for at least 4 hours a day
• Being able to read and understand Turkish
• Agreeing to participate voluntarily
• For individuals with a migraine diagnosis, having an episodic or chronic migraine diagnosis according to the International Classification of Headache Disorders Edition 3 criteria
• For individuals without a migraine diagnosis, not having a diagnosis of migraine or other primary headache.

You may not qualify if:

• A history of neurological disorder (e.g., Multiple Sclerosis)
• Inflammatory rheumatic disorders (e.g., Rheumatoid Arthritis)
• Generalized chronic pain syndromes (e.g., Fibromyalgia)
• Any other headache disease
• Any other systemic disease
• Acute fracture and infection
• Neck or spinal surgery within the last 6 months
• Serious musculoskeletal trauma within the last 6 months
• Pregnancy
• A cognitive or psychiatric condition that would prevent completion of the questionnaires
• In the control group without a migraine diagnosis, a history of recurrent headaches within the last year.

Sponsors & Collaborators

• Bozok University: lead

Related Publications (23)

• Martelletti P, de Oliveira AB, Dhamija RK, Francis P, Gouider R, Guekht A, Al-Hasany AH, Houessou MA, Lanteri-Minet M, Leonardi M, Lu-Bolanos M, Pathirage M, Malik A, Mosaddeghi-Heris R, Netravathi M, Ojha R, Owolabi MO, Paudel R, Ray J, Raggi A, Ranta A, Rathnayake N, Reuter U, Sudibyo DA, Tanprawate S, Tao J, Tu Y, Tucker L, Vashchenko N, Waidyasekara J, Wang Y, Woldeamanuel YW, Wijeratne T. Migraine, headache disorders, and brain health: aligning advocacy with the UN Sustainable Development Goals. J Headache Pain. 2026 Apr 7;27(1):94. doi: 10.1186/s10194-026-02348-5. PMID: 41947032; PMCID: PMC13054998.

  BACKGROUND

• Mohammadian M, Mollahoseini S, Naghibzadeh-Tahami A. Musculoskeletal disorders among office workers: prevalence, ergonomic risk factors, and their interrelationships. Sci Rep. 2025;15(1):45425. Epub 20251126. doi: 10.1038/s41598-025-30155-6. PubMed PMID: 41298697; PubMed Central PMCID: PMCPMC12749865.

  BACKGROUND

• Magnavita N. Headache in the Workplace: Analysis of Factors Influencing Headaches in Terms of Productivity and Health. Int J Environ Res Public Health. 2022;19(6). Epub 20220321. doi: 10.3390/ijerph19063712. PubMed PMID: 35329399; PubMed Central PMCID: PMCPMC8953285.

  BACKGROUND

• Li C, Zhang L, Zhou J, Fan Z, Wang Y, Wang X, et al. Prevalence of primary headache disorders among information technology staff in China: the negative effects of computer use and other correlative factors. BMC Public Health. 2020;20(1):443. Epub 20200405. doi: 10.1186/s12889-020-08497-9. PubMed PMID: 32248815; PubMed Central PMCID: PMCPMC7132864.

  BACKGROUND

• Côté P, van der Velde G, Cassidy JD, Carroll LJ, Hogg-Johnson S, Holm LW, et al. The burden and determinants of neck pain in workers: results of the Bone and Joint Decade 2000-2010 Task Force on Neck Pain and Its Associated Disorders. Spine (Phila Pa 1976). 2008;33(4 Suppl):S60-74. doi: 10.1097/BRS.0b013e3181643ee4. PubMed PMID: 18204402.

  BACKGROUND

• Ernst MJ, Sax N, Meichtry A, Aegerter AM, Luomajoki H, Lüdtke K, et al. Cervical musculoskeletal impairments and pressure pain sensitivity in office workers with headache. Musculoskeletal Science and Practice. 2023;66:102816. doi: https://doi.org/10.1016/j.msksp.2023.102816.

  BACKGROUND

• Marchenko M, Domingues L, Barbero M, Cescon C, Falla D, Ernst MJ. Headache, not neck pain, primarily influences the extent of pain in the neck region in symptomatic office workers. Cross-sectional and longitudinal evaluations. Physiother Theory Pract. 2025:1-11. Epub 20251212. doi: 10.1080/09593985.2025.2596179. PubMed PMID: 41384674.

  BACKGROUND

• Ernst MJ, Sax N, Meichtry A, Aegerter AM, Luomajoki H, Lüdtke K, et al. Cervical musculoskeletal impairments and pressure pain sensitivity in office workers with headache. Musculoskelet Sci Pract. 2023;66:102816. Epub 20230626. doi: 10.1016/j.msksp.2023.102816. PubMed PMID: 37394322.

  BACKGROUND

• Janwantanakul P, Pensri P, Jiamjarasrangsri V, Sinsongsook T. Prevalence of self-reported musculoskeletal symptoms among office workers. Occup Med (Lond). 2008;58(6):436-8. Epub 20080610. doi: 10.1093/occmed/kqn072. PubMed PMID: 18544589.

  BACKGROUND

• Lee S, FC DEB, CSM DEC, T DEOS. Effect of an ergonomic intervention involving workstation adjustments on musculoskeletal pain in office workers-a randomized controlled clinical trial. Ind Health. 2021;59(2):78-85. Epub 20201128. doi: 10.2486/indhealth.2020-0188. PubMed PMID: 33250456; PubMed Central PMCID: PMCPMC8010160.

  BACKGROUND

• Darivemula SB, Goswami K, Gupta SK, Salve H, Singh U, Goswami AK. Work-related Neck Pain Among Desk Job Workers of Tertiary Care Hospital in New Delhi, India: Burden and Determinants. Indian J Community Med. 2016;41(1):50-4. doi: 10.4103/0970-0218.170967. PubMed PMID: 26917874; PubMed Central PMCID: PMCPMC4746955.

  BACKGROUND

• Hwang UJ, Han J, Kwon OY, Chu YS, Yang S. Classifying office workers with and without cervicogenic headache or neck and shoulder pain using posture-based deep learning models: a multicenter retrospective study. Front Pain Res (Lausanne). 2025;6:1614143. Epub 20250707. doi: 10.3389/fpain.2025.1614143. PubMed PMID: 40692757; PubMed Central PMCID: PMCPMC12277355.

  BACKGROUND

• Waersted M, Hanvold TN, Veiersted KB. Computer work and musculoskeletal disorders of the neck and upper extremity: a systematic review. BMC Musculoskelet Disord. 2010;11:79. Epub 20100429. doi: 10.1186/1471-2474-11-79. PubMed PMID: 20429925; PubMed Central PMCID: PMCPMC2874766.

  BACKGROUND

• Houle M, Ducas J, Lardon A, Descarreaux M, Marchand AA, Abboud J. Headache-related clinical features in teleworkers and their association with coping strategies during the COVID-19 pandemic. Front Public Health. 2023;11:1303394. Epub 20231228. doi: 10.3389/fpubh.2023.1303394. PubMed PMID: 38213645; PubMed Central PMCID: PMCPMC10782858.

  BACKGROUND

• Mayma-Aguirre KJ, Burgos-Flores MA, Sabastizagal-Vela IL, Astete-Cornejo JM. Working and health conditions in teleworkers in mandatory social isolation due to COVID-19: exploratory survey in Lima and Callao. Rev Bras Med Trab. 2024;22(3):e20231139. Epub 20241114. doi: 10.47626/1679-4435-2023-1139. PubMed PMID: 39606752; PubMed Central PMCID: PMCPMC11595393.

  BACKGROUND

• Alaca N, Acar A, Öztürk S. Low back pain and sitting time, posture and behavior in office workers: A scoping review. J Back Musculoskelet Rehabil. 2025;38(5):919-43. Epub 20250320. doi: 10.1177/10538127251320320. PubMed PMID: 40111906.

  BACKGROUND

• Ashina S, Lipton RB, Bendtsen L, Hajiyeva N, Buse DC, Lyngberg AC, et al. Increased pain sensitivity in migraine and tension-type headache coexistent with low back pain: A cross-sectional population study. Eur J Pain. 2018;22(5):904-14. Epub 20180119. doi: 10.1002/ejp.1176. PubMed PMID: 29349847.

  BACKGROUND

• Al-Khazali HM, Younis S, Al-Sayegh Z, Ashina S, Ashina M, Schytz HW. Prevalence of neck pain in migraine: A systematic review and meta-analysis. Cephalalgia. 2022;42(7):663-73. Epub 20220215. doi: 10.1177/03331024211068073. PubMed PMID: 35166137.

  BACKGROUND

• Matharu M, Katsarava Z, Buse DC, Sommer K, Reed ML, Fanning KM, et al. Characterizing neck pain during headache among people with migraine: Multicountry results from the Chronic Migraine Epidemiology and Outcomes - International (CaMEO-I) cross-sectional study. Headache. 2024;64(7):750-63. Epub 20240622. doi: 10.1111/head.14753. PubMed PMID: 38982663.

  BACKGROUND

• Rees TA, Doukhi D, Wang VS, Balcerbula A, Bravo M, Fathi H, et al. Neck pain in migraine: A narrative review and steps to correct evaluation and treatment. Cephalalgia. 2025;45(10):3331024251387449. Epub 20251024. doi: 10.1177/03331024251387449. PubMed PMID: 41134815.

  BACKGROUND

• de Tommaso M, Sciruicchio V. Migraine and Central Sensitization: Clinical Features, Main Comorbidities and Therapeutic Perspectives. Curr Rheumatol Rev. 2016;12(2):113-26. doi: 10.2174/1573397112666151231110813. PubMed PMID: 26717950.

  BACKGROUND

• Dodick D, Silberstein S. Central sensitization theory of migraine: clinical implications. Headache. 2006;46 Suppl 4:S182-91. doi: 10.1111/j.1526-4610.2006.00602.x. PubMed PMID: 17078850.

  BACKGROUND

• Aydinlar B, Bozkurt E, Senel A, Erdogan Soyukibar T, Acar E. Factors negatively affecting a migraine-friendly workplace in healthcare. Int J Occup Saf Ergon. 2025:1-7. Epub 20250926. doi: 10.1080/10803548.2025.2556615. PubMed PMID: 41005315

  BACKGROUND

MeSH Terms

Conditions

Migraine Disorders; Musculoskeletal Pain; Occupational Stress

Condition Hierarchy (Ancestors)

Headache Disorders, Primary; Headache Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Muscular Diseases; Musculoskeletal Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Occupational Diseases; Stress, Psychological; Behavioral Symptoms; Behavior

Study Officials

• Dilara Onan, PhD

  Yozgat Bozok University

  PRINCIPAL INVESTIGATOR

• Merve Ceren Akgör, Neurologist

  Department of Neurology, University of Health Sciences, Ankara Atatürk Sanatorium Training and Research Hospital, Ankara, Türkiye

  STUDY CHAIR

• Doğan Porsnok, PhD

  Bingol University

  STUDY CHAIR

• Pelin Yenilmez Yeşildaş, Neurologist

  Gaziantep City Hospital

  STUDY CHAIR

Central Study Contacts

Dilara ONAN, PhD

CONTACT

+905358642234; dilaraonan@gmail.com

Pelin YENİLMEZ YEŞİLDAŞ, Neurologist

CONTACT

+905392040612; pelinnyenilmez@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 21, 2026
• First Posted: April 28, 2026
• Study Start: April 23, 2026
• Primary Completion (Estimated): May 10, 2026
• Study Completion (Estimated): May 11, 2026
• Last Updated: May 4, 2026

Record last verified: 2026-04