Clinical Practices of Extubation After Invasive Mechanical Ventilation

NCT07554586 | Not Yet Recruiting

• 1 other identifier: IRB_26.04.01
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Extubation is a delicate and complex phase of airway management in anesthesia and critical care. A variety of complications are of concern, ranging from transient hypoxemia to the need for reintubation, which can then become life-threatening for the patient. For this procedure, it may be recommended to use the positive end-expiratory pressure (PEEP) extubation technique to reduce the risks of hypoxemia, atelectasis, and aspiration. However, no specific technique is preferred given the diversity of described procedures (spontaneous ventilation on an auxiliary circuit, PEEP-assisted spontaneous ventilation, adjustment of the APL valve). However, results may vary depending on the patient population (children, adults) and the setting (operating room, intensive care unit). Given the lack of a preferred technique for performing extubation under positive end-expiratory pressure, the aim of this study is to describe the techniques used by healthcare professionals (physicians, nurse anesthetists, nurses) during the extubation of a surgical or intensive care patient.

Conditions

Extubation; Anesthesia; Mechanical Ventilation; Critical Care, Intensive Care

Outcome Measures

Primary Outcomes (1)

• Extubation technique

  Frequency of use of the simple suction extubation technique compared to the positive-pressure extubation technique (%)

  baseline

Study Arms (1)

Caregivers performing extubation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Healthcare personnel responsible for routinely extubating surgical patients during the recovery and resuscitation phases as they are weaned off invasive ventilation.

You may qualify if:

• Physicians and students in anesthesiology and critical care,
• Critical care physicians,
• State-certified nurse anesthetists (IADE),
• State-certified nurses (IDE) working in an anesthesia or intensive care team
• Students (medical or nurse anesthetist) with at least 1 year of extubation experience.

You may not qualify if:

• Healthcare professionals with no experience in extubation (less than one year of practice) Refusal to participate

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nīmes: lead

Study Sites (1)

CHU de Nîmes

Nîmes, 30000, France

Location

Study Officials

• Anissa MEGZARI

  Centre Hospitalier Universitaire de Nīmes

  STUDY DIRECTOR

Central Study Contacts

Jean Yves LEFRANT, PHD

CONTACT

+33 466 68 30 50; jean.yves.lefrant@chu-nimes.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 21, 2026
• First Posted: April 28, 2026
• Study Start: April 28, 2026
• Primary Completion (Estimated): October 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: May 4, 2026

Record last verified: 2026-04

Locations

FR (1)