Dental Management of Patients With HIV in Pays de la Loire

NCT07552038 | Not Yet Recruiting

• 1 other identifier: AP_GADV_SG_VIH-ODONTO
• Study Type: observational
• Target: 5,603
• Locations: 0 countries
• Sites: N/A

Brief Summary

Dental care for people living with HIV has evolved with the widespread use of antiretroviral therapy, which has improved life expectancy and disease control. However, uncertainty remains about whether specific adaptations are still needed during dental procedures due to potential biological abnormalities that may increase infectious or bleeding risks. This study aims to evaluate the proportion of patients living with HIV in the Pays de la Loire region who may require adapted dental management based on biological parameters such as immune status, hematological values, and comorbidities. A retrospective descriptive study will be conducted using anonymized data from 5,603 patients followed in the COREVIH Pays de la Loire database. The results are expected to provide objective data to better inform dental practice and reduce unnecessary precautions or stigmatization in the management of patients living with HIV.

Conditions

HIV Infection; Acquired Immune Deficiency Syndrome; Oral Health Care

Outcome Measures

Primary Outcomes (1)

• Proportion of Patients Requiring Adapted Dental Management

  Percentage of patients living with HIV presenting at least one biological abnormality associated with increased risk of infectious or hemorrhagic complications during invasive dental procedures, including low CD4 count, neutropenia, thrombocytopenia, or anemia, based on routinely collected clinical data.

  At time of data extraction (retrospective baseline)

Secondary Outcomes (6)

• CD4 Cell Count Distribution

  At time of data extraction (retrospective baseline)

• Neutrophil Count Distribution

  At time of data extraction (retrospective baseline)

• Platelet Count Distribution

  At time of data extraction (retrospective baseline)

• Hemoglobin Level Distribution

  At time of data extraction (retrospective baseline)

• Prevalence of Comorbidities

  At time of data extraction (retrospective baseline)

Study Arms (1)

Patients With HIV

Patients living with HIV included in a retrospective cohort using anonymized data from the COREVIH Pays de la Loire database. The study population includes adults followed in routine clinical care, with available demographic, clinical, biological, and comorbidity data used to assess factors relevant to dental management.

Other: HIV infection status and clinical characteristics

Interventions

HIV infection status and clinical characteristics OTHER

Observational assessment of clinical, biological, and comorbidity data in patients living with HIV, including CD4 count, viral load, hematological parameters, and associated conditions, collected from routine care without any intervention.

Patients With HIV

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients living with HIV followed in hospital-based infectious diseases departments in France, identified retrospectively from routine clinical records and biological databases.

You may qualify if:

• Adult patients aged ≥18 years
• Confirmed diagnosis of HIV infection
• Followed at participating hospital centers
• Available clinical and biological data relevant to dental care management (CD4 count, viral load, blood count)

You may not qualify if:

• Patients with missing key biological data required for analysis
• Patients not followed in participating centers
• Patients with incomplete medical records preventing assessment of outcomes

Sponsors & Collaborators

• Nantes University Hospital: lead

MeSH Terms

Conditions

HIV Infections; Acquired Immunodeficiency Syndrome

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Slow Virus Diseases

Central Study Contacts

Gilles Amador del Valle, MD, PhD

CONTACT

+33 2 40 08 31 73; gilles.amadordelvalle@univ-nantes.fr

Alexandra Poinas, PhD

CONTACT

+33 2 53 48 28 57; alexandra.poinas@chu-nantes.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 20, 2026
• First Posted: April 27, 2026
• Study Start: May 2, 2026
• Primary Completion (Estimated): May 30, 2026
• Study Completion (Estimated): May 30, 2026
• Last Updated: April 27, 2026

Record last verified: 2026-04