NCT07550829

Brief Summary

This study investigated the effects of three exercise modalities: aerobic exercise, resistance exercise, and combined exercise on the risk of arteriosclerosis in sedentary postmenopausal women.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
113

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Feb 2025

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 15, 2025

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 30, 2025

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2025

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

April 20, 2026

Completed
4 days until next milestone

First Posted

Study publicly available on registry

April 24, 2026

Completed
Last Updated

April 24, 2026

Status Verified

May 1, 2025

Enrollment Period

6 months

First QC Date

April 20, 2026

Last Update Submit

April 20, 2026

Conditions

Sedentary

Keywords

Combined exerciseArteriosclerosisSedentaryPostmenopausal women

Outcome Measures

Primary Outcomes (11)

  • Flow mediated dilation (FMD)

    The change of flow mediated dilation before and after intervention.

    12 weeks

  • Brachial ankle pulse wave velocity (baPWV)

    The change of baPWV before and after intervention.

    12 weeks

  • Ankle brachial index (ABI)

    The change of ABI before and after intervention.

    12 weeks

  • Carotid intima-media thickness (cIMT)

    The change of cIMT before and after intervention.

    12 weeks

  • Systolic blood pressure (SBP)

    The change of SBP before and after intervention.

    12 weeks

  • Diastolic blood pressure (DBP)

    The change of DBP before and after intervention.

    12 weeks

  • Peak systolic velocity (PSV)

    The change of PSV of carotid artery before and after intervention.

    12 weeks

  • End diastolic velocity (EDV)

    The change of EDV of carotid artery before and after intervention.

    12 weeks

  • Pulsatility index (PI)

    The change of PI of carotid artery before and after intervention.

    12 weeks

  • Resistance index (RI)

    The change of RI of carotid artery before and after intervention.

    12 weeks

  • Wall Shear Stress (WSS)

    The change of WSS of carotid artery before and after intervention.

    12 weeks

Secondary Outcomes (30)

  • Nitric oxide (NO)

    12 weeks

  • Prostacyclin (PGI2)

    12 weeks

  • Endothelin-1 (ET-1)

    12 weeks

  • Angiotensin II (AngII)

    12 weeks

  • C-Reactive protein (CRP)

    12 weeks

  • +25 more secondary outcomes

Study Arms (4)

AE group

ACTIVE COMPARATOR
Behavioral: AE group

RE group

ACTIVE COMPARATOR
Behavioral: RE group

CE group

ACTIVE COMPARATOR
Behavioral: CE group

CON group

ACTIVE COMPARATOR
Behavioral: ON group

Interventions

AE groupBEHAVIORAL

Aerobic exercise

AE group
RE groupBEHAVIORAL

Resistance exercise

RE group
CE groupBEHAVIORAL

Combined exercise

CE group
ON groupBEHAVIORAL

No intervention

CON group

Eligibility Criteria

Age45 Years - 69 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Participants have been postmenopausal for more than 12 months and have not received any exogenous estrogen supplementation after menopause.
  • Participants were screened using the International Physical Activity Questionnaire-Short Form (IPAQ-S), with a physical activity level classified as "low." They must not have engaged in moderate-intensity physical activity for at least 3 days per week, with a duration of no less than 30 minutes per day, for over 3 consecutive months.
  • Participants were screened using the Physical Activity Readiness Questionnaire+ (PAR-Q+) and be deemed safe to undergo further intervention.

You may not qualify if:

  • Participants with acute or chronic musculoskeletal disorders, cardiovascular diseases, or similar conditions.
  • Participants with abnormal blood pressure: resting systolic blood pressure \>140 mmHg or diastolic blood pressure \>90 mmHg, or those taking antihypertensive medications.
  • Participants with abnormally high arterial stiffness (within pathological range): brachial-ankle pulse wave velocity (baPWV) \>1800 cm/s.
  • Participants recently taken medications that may affect blood indicators, such as hormones or anti-inflammatory drugs.
  • Participants with unstable body weight in the past 3 months (fluctuation greater than ±2.5 kg).
  • Participants currently participating in other intervention studies or those with regular exercise habits in daily life.
  • Participants who smoke or consume alcohol regularly.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

School of Sports Medicine and Rehabilitation, Beijing Sport University

Beijing, China

Location

MeSH Terms

Conditions

Sedentary BehaviorArteriosclerosis

Interventions

Rhced protein, mouse

Condition Hierarchy (Ancestors)

BehaviorArterial Occlusive DiseasesVascular DiseasesCardiovascular Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 20, 2026

First Posted

April 24, 2026

Study Start

February 15, 2025

Primary Completion

July 30, 2025

Study Completion

December 30, 2025

Last Updated

April 24, 2026

Record last verified: 2025-05

Locations

CN(1)