The Effect of Periurethral Injection of Platelet Rich Plasma Versus Mid-urethral Sling in Treatment of Stress Urinary Incontinence : a Randomized Clinical Trial

NCT07550426 | Not Yet Recruiting DMC

• 1 other identifier: FMASU MD285/2025
• Study Type: interventional
• Target: 42
• Locations: 0 countries
• Sites: N/A

Brief Summary

this study used to compare efficacy between platelet rich plasma periurethral injection versus mid urethral sling ( trans obturator tape ) in treatment of stress urinary incontinence

Conditions

Stress Urinary Incontinence (SUI)

Outcome Measures

Primary Outcomes (1)

• objective assessment of SUI through cough stress test

  after one and three months

Study Arms (1)

patients complaining of stress urinary incontinence based on urodynamic study

EXPERIMENTAL

GROUP 1: 21 patients allocated who have SUI ISD will receive PRP GROUP 2: 21 patient who have hypermobile urethra will receive TOT

Procedure: Platelet Rich Plasma; Procedure: Mid urethral sling ( trans obturator tape)

Interventions

Platelet Rich Plasma PROCEDURE

GROUP 1 : 21patient will have platelet rich plasma injected periurethral in intrinsic muscle weakness in stress urinary incontinence

patients complaining of stress urinary incontinence based on urodynamic study

Mid urethral sling ( trans obturator tape) PROCEDURE

GROUP 2 : (21) patient having SUI due to hypermobile urethra will have TOT

patients complaining of stress urinary incontinence based on urodynamic study

Eligibility Criteria

• Age: 26 Years - 66 Years
• Gender Eligibility Details: because it depend on female genitourinary system urethral anatomy
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• stress urinary incontinence identified by urodynamic study
• patient agreement to undergo surgical treatment

You may not qualify if:

• previous GUS operation
• evidence of detrusor overactivity urinary system
• presence of pelvic organ prolapse
• malignancies of genitourinary system
• history of hemorrhagic disorders , on anti platelet treatment , uncontrolled diabetes mellitus .

Sponsors & Collaborators

• Ain Shams University: lead

MeSH Terms

Conditions

Urinary Incontinence, Stress

Interventions

Suburethral Slings

Condition Hierarchy (Ancestors)

Urinary Incontinence; Urination Disorders; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Lower Urinary Tract Symptoms; Urological Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Prostheses and Implants; Equipment and Supplies

Study Officials

• mohamed Abdelhamid nasr El Din, Doctor of medicine

  urogynecology unit ainshams university

  STUDY DIRECTOR

Central Study Contacts

nahla fathy khatab, master of science

CONTACT

01030241711; nahlafathy1995@gmail.com

mahmoud mohamed Ghaleb, Doctor of medicine

CONTACT

02 01007212975

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: randomized controlled clinical trial

Study Record Dates

• First Submitted: April 18, 2026
• First Posted: April 24, 2026
• Study Start: April 15, 2026
• Primary Completion (Estimated): April 15, 2027
• Study Completion (Estimated): December 30, 2027
• Last Updated: April 24, 2026

Record last verified: 2025-10

Data Sharing

• IPD Sharing: Will not share