Investigation of Imagery Abilities in Individuals With Migraine
1 other identifier
observational
126
0 countries
N/A
Brief Summary
The aim of this study is to compare the motor imagery abilities of patients with migraine to those of healthy individuals, and to examine the relationship between motor imagery and proprioception (cervical and trunk), balance, body awareness, anxiety, and depression levels. Additionally, the study aims to investigate the relationship between proprioception and balance in patients with migraine. Motor imagery abilities of patients with migraine and healthy control subjects (aged 18-65 years; planned sample size: 68 individuals in each group, 68 migraine patients and 68 healthy participants) will be assessed using the Movement Imagery Questionnaire-3, the Motor Imagery Ability Test, mental chronometry, mental rotation tasks, and functional MRI (fMRI) during motor imagery of different tasks. Additionally, in patients with migraine, cervical and trunk proprioception, balance, body awareness, the Tampa Scale for Kinesiophobia, the Vertigo Symptom Scale, the Dizziness Handicap Inventory, and the Hospital Anxiety and Depression Scale will be evaluated.
- 1.Hypothesis H0: There is no difference in motor imagery abilities between patients with migraine and healthy controls.
- 2.Hypothesis H0: There is no relationship between motor imagery abilities and proprioception in patients with migraine. H1: There is a relationship between motor imagery abilities and proprioception in patients with migraine.
- 3.Hypothesis H0: There is no relationship between proprioception (cervical/trunk) and balance in patients with migraine.
- 4.Hypothesis H0: There is no relationship between motor imagery abilities and body awareness, anxiety, and depression in patients with migraine.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Sep 2026
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 4, 2026
CompletedFirst Posted
Study publicly available on registry
April 22, 2026
CompletedStudy Start
First participant enrolled
September 16, 2026
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 30, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
August 30, 2027
September 28, 2026
April 1, 2026
5 months
April 4, 2026
September 23, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (8)
Headache Assessment: Numerical Pain Scale
The numeric pain scale is used to assess the severity of a headache.The pain a person feels is evaluated on a scale from "0: no pain at all" to "10: I feel very severe pain."
From August 2026 to January 2027
Movement Imagery Questionnaire-3
The Movement Imagery Questionnaire-3 is the most up-to-date version of the Movement Imagery Questionnaire and the Movement Imagery Questionnaire-Revised, Second Edition.The questionnaire consists of 12 items and separately evaluates external, internal, and kinesthetic imagery abilities. After each imagery task, individuals rate their experience on a scale from 1 to 7 (1 - very difficult to feel/see, 7 - very easy to feel/see).
From August 2026 to January 2027
Motor Imagery Ability Test
The ability to imagine movement is used to test the controllability component of imagery (CC). It is defined as the ability to manipulate, transform, or maintain an imagined body movement over time
From August 2026 to January 2027
Mental Chronometry
The administration of questionnaires is quite easy and quick. However, the subjectivity arising from individuals rating themselves in these questionnaires should not be overlooked. Mental chronometry can be defined as the time required by the neural system to process information. It is based on a different foundation than the questionnaires mentioned above. Mental chronometry is a parameter that measures the duration of motor imagery and is based on the assumption that the time required to perform a movement is the same as the time needed to imagine it. Compared to questionnaires, mental chronometry is a more objective measure; however, it does not evaluate the clarity or vividness of imagery. Mental chronometry measurements are planned to be carried out using the method described by Oostra et al.
From August 2026 to January 2027
Mental Rotation Ability
Mental Rotation is one of the visuospatial abilities and can be simply defined as the mental rotation of objects in three dimensions. To evaluate mental rotation ability, three-dimensional objects such as cubes or body parts like the hands and feet can be used. Mental rotation ability is frequently assessed using hand images. The basic principle of hand mental rotation tests is to determine whether a hand image, presented from different angles and orientations, belongs to the right or left hand. In our study, since we focus on the neck region and balance ability, the Recognise Neck and Foot applications, which include images of the neck and feet, will be used.
From August 2026 to January 2027
Assessment of motor imagery of different tasks using Functional Magnetic Resonance Imaging
The task is to perform visual motor imagery and kinesthetic motor imagery in accordance with the instructions, taking into account the tasks included in the Movement Imagery Questionnaire-3.The stimuli will be presented via projection onto a mirror mounted on the head coil of the Functional Magnetic Resonance Imaging scanner. All participants will first be instructed to perform visual motor imagery (first-person internal egocentric imagery) and then kinesthetic motor imagery. The procedure is planned to be carried out using the method applied by Kwon et al.
From August 2026 to January 2027
The Montreal Cognitive Assessment
The Montreal Cognitive Assessment is a neuropsychological test used to evaluate cognitive domains such as memory, attention, executive functions, visuospatial abilities, language, abstraction, and orientation. The scale includes items assessing attention and concentration, executive functions, memory, language, visuospatial skills, abstract thinking, calculation, and orientation. The total score ranges from 0 to 30. In the standardization study conducted in our country, the cutoff score for distinguishing healthy individuals from those with mild cognitive impairment was determined as 21.
From August 2026 to January 2027
The Migraine Disability Assessment
The Migraine Disability Assessment scale measures headache-related disability and includes five functional questions related to work, school, and household activities. The MIDAS score is calculated by counting the number of days in which the patient's performance is reduced or absent.
From August 2026 to January 2027
Secondary Outcomes (4)
Cervical Proprioception Assessment
from August 2026 to January 2027
Trunk Proprioception Assessment
from August 2026 to January 2027
Neck Awareness Assement
from August 2026 to January 2027
Balance Assessment
from August 2026 to January 2027
Other Outcomes (5)
Body Awareness Questionnaire
from August 2026 to January 2027
The Tampa Scale for Kinesiophobia
From August 2026 to January 2027
The Vertigo Symptom Scale
From August 2026 to January 2027
- +2 more other outcomes
Study Arms (2)
migraine patients
Healthy Participants
Eligibility Criteria
migraine patients
You may qualify if:
- Migraine Patients:
- Diagnosed with migraine by a neurologist according to ICHD-3 criteria
- Aged 18-65 years
- Score greater than 21 on the Montreal Cognitive Assessment (MoCA)
- Healthy Participants:
- Aged 18-65 years
- Score greater than 21 on the Montreal Cognitive Assessment (MoCA)
You may not qualify if:
- (for both migraine and healthy control groups):
- Presence of additional neurological or orthopedic disorders
- Current use of psychiatric medications
- Severe musculoskeletal, cardiovascular, pulmonary, metabolic, or other medical conditions that would prevent participation in the study
- Significant visual or hearing impairments
- Severe cognitive impairment, as determined by a physician, that would interfere with the administration of tests.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Target Duration
- 2 Days
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Specialist Physical Therapist, Principal Investigator
Study Record Dates
First Submitted
April 4, 2026
First Posted
April 22, 2026
Study Start
September 16, 2026
Primary Completion (Estimated)
January 30, 2027
Study Completion (Estimated)
August 30, 2027
Last Updated
September 28, 2026
Record last verified: 2026-04