Assessment of Risk Factors for Acquiring Colonization With Candida Auris During an Outbreak in ICU.

NCT07544342 | Active Not Recruiting

• 1 other identifier: BRZ-0103-25
• Study Type: observational
• Target: 1,200
• Locations: 1 country
• Sites: 1

Brief Summary

The study is aimed to assess the risk factors for acquiring candida auris skin colonization during an outbreak in an ICU.

Conditions

Candida Auris Colonization

Keywords

colonization; ICU; candida auris

Outcome Measures

Primary Outcomes (1)

• Colonization with Candida auris

  Positive screening for candida auris, taken by nose/ armpits and groin swabs and either directly seeded on a selective medium or by positive PCR.

  From hospitalization in ICU until 2 weeks following discharge from ICU, a maximum of 90 days.

Study Arms (2)

Non colonized

Patient not colonized with candida auris

Colonized

Patient colonized with candida auris

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients hospitalized in ICU

You may qualify if:

• hospitalization in ICU
• Screened for candida auris

You may not qualify if:

• Age \<18 yeas.
• No data.
• No candida screen.

Sponsors & Collaborators

• Barzilai Medical Center: lead

Study Sites (1)

Barzilai Medical Center

Ashkelon, Israel

Location

Related Publications (5)

• Rossow J, Ostrowsky B, Adams E, Greenko J, McDonald R, Vallabhaneni S, Forsberg K, Perez S, Lucas T, Alroy KA, Jacobs Slifka K, Walters M, Jackson BR, Quinn M, Chaturvedi S, Blog D; New York Candida auris Investigation Workgroup. Factors Associated With Candida auris Colonization and Transmission in Skilled Nursing Facilities With Ventilator Units, New York, 2016-2018. Clin Infect Dis. 2021 Jun 1;72(11):e753-e760. doi: 10.1093/cid/ciaa1462.

  PMID: 32984882 BACKGROUND

• Ruiz-Gaitan A, Martinez H, Moret AM, Calabuig E, Tasias M, Alastruey-Izquierdo A, Zaragoza O, Mollar J, Frasquet J, Salavert-Lleti M, Ramirez P, Lopez-Hontangas JL, Peman J. Detection and treatment of Candida auris in an outbreak situation: risk factors for developing colonization and candidemia by this new species in critically ill patients. Expert Rev Anti Infect Ther. 2019 Apr;17(4):295-305. doi: 10.1080/14787210.2019.1592675. Epub 2019 Mar 29.

  PMID: 30922129 BACKGROUND

• Mulet Bayona JV, Tormo Palop N, Salvador Garcia C, Guna Serrano MDR, Gimeno Cardona C. Candida auris from colonisation to candidemia: A four-year study. Mycoses. 2023 Oct;66(10):882-890. doi: 10.1111/myc.13626. Epub 2023 Jul 4.

  PMID: 37401661 BACKGROUND

• Proctor DM, Dangana T, Sexton DJ, Fukuda C, Yelin RD, Stanley M, Bell PB, Baskaran S, Deming C, Chen Q, Conlan S, Park M; NISC Comparative Sequencing Program; Welsh RM, Vallabhaneni S, Chiller T, Forsberg K, Black SR, Pacilli M, Kong HH, Lin MY, Schoeny ME, Litvintseva AP, Segre JA, Hayden MK. Integrated genomic, epidemiologic investigation of Candida auris skin colonization in a skilled nursing facility. Nat Med. 2021 Aug;27(8):1401-1409. doi: 10.1038/s41591-021-01383-w. Epub 2021 Jun 21.

  PMID: 34155414 BACKGROUND

• Shastri PS, Shankarnarayan SA, Oberoi J, Rudramurthy SM, Wattal C, Chakrabarti A. Candida auris candidaemia in an intensive care unit - Prospective observational study to evaluate epidemiology, risk factors, and outcome. J Crit Care. 2020 Jun;57:42-48. doi: 10.1016/j.jcrc.2020.01.004. Epub 2020 Jan 9.

  PMID: 32062286 BACKGROUND

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of infection control

Study Record Dates

• First Submitted: February 15, 2026
• First Posted: April 22, 2026
• Study Start: February 15, 2026
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): September 1, 2026
• Last Updated: April 22, 2026

Record last verified: 2026-02

Locations

IL (1)