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PBM
The Impact of Implementing a Hospital-wide Patient Blood Management (PBM) Program on Blood Product Utilization and Maternal Outcomes in All Obstetric Deliveries: a Retrospective Observational Study (2018-2025)
Sponsor study identifier
observational
44,000
1 country
1
Study Start
February 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Obstetric anemia and hemorrhage are major causes of maternal morbidity and increased healthcare utilization. Although red blood cell (RBC) transfusion is commonly used, it is associated with higher rates of postpartum complications, including pneumonia, renal failure, and cardiac events (Kloka et al.). Patient Blood Management (PBM) is an evidence-based approach that aims to optimize a patient's own blood and reduce avoidable transfusion through three pillars: treating anemia and iron deficiency, minimizing blood loss, and avoiding unnecessary transfusion. International guidelines support PBM in obstetrics, but data on comprehensive program implementation remain limited due to barriers such as resource constraints and the need for multidisciplinary coordination. Aims , objectives and Hypotheses Primary Aim To assess the association between PBM implementation and blood product utilisation among all obstetric deliveries at Corniche Hospital between 2018 and 2025. Primary Objective To estimate the change over time in the mean number of blood product units transfused per delivery (combined and by product type). Primary Hypothesis Increasing PBM maturity over time, particularly following comprehensive PBM implementation in 2022, is associated with a significant reduction in mean blood product units transfused per delivery, after adjusting for changes in case-mix. Secondary Objectives Secondary objectives include evaluating changes in transfusion-related practice and anemia outcomes, including proportion of deliveries receiving any transfusion; pretransfusion hemoglobin thresholds in non-actively bleeding patients (where definable); predelivery anemia prevalence (and iron therapy utilization where captured). Maternal outcomes will be evaluated by reporting composite morbidity; postpartum hysterectomy; hospital length of stay; High Dependency unit (HDU)/ICU admission and length of stay; 28-day all-cause emergency readmissions; in-hospital mortality. Neonatal outcomes will not be included. At Corniche Hospital, prior evaluation in cases of major obstetric hemorrhage showed that PBM reduced blood product use and improved hemoglobin recovery without increasing morbidity (Ansari et al.). This study extends the assessment to all deliveries from 2018-2025 to evaluate hospital-wide changes in transfusion practice and maternal outcomes as PBM implementation matured.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 18, 2026
Actual (reported)April 22, 2026
Actual (reported)February 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Mean number of blood product units transfused per delivery
measured combined units of RBC, FFP and platelet units measured per delivery
2018 - 2025
Proportion of deliveries receiving any blood product (RBC/FFP/platelets)
2018-2025
Mean pretransfusion Hb in non-actively bleeding patients (where definable)
2018-2025
Predelivery anemia prevalence (define threshold consistent with local policy; e.g., Hb <11g/dL)
2018-2025
Utilization of IV iron pre- and post-delivery (if available and reliable)
2018-2025
Composite morbidity
2018-2025
All women who delivered at corniche during the study period regardless of the type of delivery: vaginal, operative vaginal, cesarean section (including livebirth or stillbirth)
Corniche Hospital
Abu Dhabi, United Arab Emirates
Kloka JA, Friedrichson B, Jasny T, Old O, Piekarski F, Zacharowski K, Neef V. Anemia, red blood cell transfusion and administration of blood products in obstetrics: a nationwide analysis of more than 6 million cases from 2011-2020. Blood Transfus. 2024 Jan;22(1):37-45. doi: 10.2450/BloodTransfus.528. Epub 2023 Sep 15.
Ansari T, Wani S, Hofmann A, Shetty N, Sangani K, Stamp CJ, Murray K, Trentino KM. Outcomes Associated with a Patient Blood Management Program in Major Obstetric Hemorrhage: A Retrospective Cohort Study. Anesth Analg. 2026 Jan 1;142(1):114-123. doi: 10.1213/ANE.0000000000007292. Epub 2024 Nov 21.
Tarek Ansari, FFARCSI
Corniche Hospital
First Submitted
March 18, 2026
First Posted
April 22, 2026
Study Start
February 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Primary Completion
June 2027
Contact the study team to confirm eligibility.
Munoz M, Stensballe J, Ducloy-Bouthors AS, Bonnet MP, De Robertis E, Fornet I, Goffinet F, Hofer S, Holzgreve W, Manrique S, Nizard J, Christory F, Samama CM, Hardy JF. Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement. Blood Transfus. 2019 Mar;17(2):112-136. doi: 10.2450/2019.0245-18. Epub 2019 Feb 6.
Shaylor R, Weiniger CF, Austin N, Tzabazis A, Shander A, Goodnough LT, Butwick AJ. National and International Guidelines for Patient Blood Management in Obstetrics: A Qualitative Review. Anesth Analg. 2017 Jan;124(1):216-232. doi: 10.1213/ANE.0000000000001473.
Surbek D, Vial Y, Girard T, Breymann C, Bencaiova GA, Baud D, Hornung R, Taleghani BM, Hosli I. Patient blood management (PBM) in pregnancy and childbirth: literature review and expert opinion. Arch Gynecol Obstet. 2020 Feb;301(2):627-641. doi: 10.1007/s00404-019-05374-8. Epub 2019 Nov 14.
Planned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
June 2027
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 21, 2026
Record last verified: 2026-10
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