Effectiveness of Laser Acupuncture in Improving Arterial Stiffness Among Patients With Cardiorenal Metabolic Syndrome

NCT07543211 | Not Yet Recruiting

• 1 other identifier: NYCU114227AEF
• Study Type: observational
• Target: 35
• Locations: 0 countries
• Sites: N/A

Brief Summary

Background: Cardio-renal metabolic syndrome (CRMS) is a vicious cycle of cardiac, renal, and metabolic disease, representing a high-risk for atherosclerosis. Laser acupuncture modulates vascular inflammation and improves endothelial function via low-level laser therapy (LLLT, \<500mW) at acupoints or musculoskeletal pain sites. Few studies have focused on CRMS populations. This study evaluates laser acupuncture effects on arterial stiffness in CRMS. Purpose: To assess the effects of improvement of laser acupuncture in patients with CRMS, and to evaluate its feasibility as supportive therapy. Methods: A single-group pre-post design is used. Participants are patients with CRMS receiving laser acupuncture at a Chinese medicine clinic in Taiwan. CRMS is interrelated by cardiac, renal, and metabolic disease. Inclusion criteria require diagnosis in ≥2 of 3 systems (cardiovascular, renal, or metabolic; n = 35). Laser acupuncture will be applied to bilateral BL40 for 12 weeks (1-3 sessions/week, 60mins/session). Pulse wave velocity(PWV) measured by Omron HBP- 8000 as the primary outcome for arterial stiffness. Paired t-tests and GEE will be used for analysis. Expected Results: PWV is expected to show significant improvement after intervention.

Conditions

Hypertension; Diabetes Mellitus; Chronic Kidney Disease; Cardio-Renal-Metabolic Syndrome

Outcome Measures

Primary Outcomes (1)

• Change in Pulse Wave Velocity (PWV)

  Baseline and after 12 weeks of treatment

Interventions

laser acupuncture OTHER

Low-level laser therapy applied to acupuncture points as part of routine clinical treatment. No additional intervention is assigned for research purposes.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants are adult patients diagnosed with cardio-renal-metabolic syndrome who are receiving routine laser acupuncture treatment in a clinical setting. The study population includes individuals with conditions such as hypertension, diabetes mellitus, chronic kidney disease, or dyslipidemia.

You may qualify if:

• Age 18 years or older
• Diagnosed with at least two conditions related to cardio-renal-metabolic syndrome (e.g., hypertension, diabetes mellitus, chronic kidney disease, or dyslipidemia)
• Receiving routine laser acupuncture treatment in a clinical setting
• Able to understand the study procedures and provide informed consent

You may not qualify if:

• Presence of acute cardiovascular events (e.g., acute myocardial infarction, stroke)
• Acute kidney injury
• Presence of medical devices or conditions that contraindicate the use of laser acupuncture at the treatment site (e.g., arteriovenous shunt)
• Unable to complete the study procedures or follow-up assessments

Sponsors & Collaborators

• National Yang Ming Chiao Tung University: lead

MeSH Terms

Conditions

Hypertension; Diabetes Mellitus; Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 15, 2026
• First Posted: April 21, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: April 21, 2026

Record last verified: 2026-04