Trials Sponsors Conditions Drugs Pricing

Conditions

Alveolar Bone Density and Postoperative Pain Management Odontectomy (Tooth Extraction)Periapical Radiolucency Socket Preservation and Healing Following Simple, Non-surgical Extraction

Keywords

Concentrated Growth Factor (CGF)CGF PlugOdontectomyTooth ExtractionSocket PreservationBone DensityPostoperative PainAlveolar BonePlatelet Concentrates

Outcome Measures

Primary Outcomes (2)

Bone Density
Evaluation of the extraction socket using Cone-beam computed tomography (CBCT) to assess changes in bone healing and preservation. Measurements are specifically analyzed and recorded using the Hounsfield unit scale to quantify mineral density within the site.
Baseline assessment is conducted immediately after the tooth extraction and CGF plug placement, with a follow-up assessment performed at 3 months postoperatively.
Post Operative Pain
Clinical evaluation of pain using the Verbal Numeric Rating Scale (VNRS), where participants rate their pain on a scale from 0 to 10 (0 = No pain, 10 = Worst imaginable pain).
Assessments are conducted at three specific intervals: Day 1, Day 3, and Day 7 following the surgical procedure.

Study Arms (1)

CGF Plug Intervention Group

EXPERIMENTAL

This arm involves patients requiring simple, non-surgical extraction of a single tooth. Following an atraumatic extraction and socket curettage, a Concentrated Growth Factor (CGF) plug is packed into the fresh odontectomy site. The CGF plug is prepared by centrifuging 10 mL of the patient's own blood using a specialized variable-speed protocol to create a dense fibrin matrix. After the plug is inserted, the wound is secured with Vicryl sutures. Participants in this arm are evaluated for changes in bone density via CBCT imaging and for postoperative pain using the Verbal Numeric Rating Scale (VNRS).

Other: Concentrated Growth Factor (CGF) Plug

Interventions

Concentrated Growth Factor (CGF) PlugOther

The intervention involves preparing an autologous Concentrated Growth Factor (CGF) plug from the patient's blood using variable-speed centrifugation and placing it into a fresh, curetted extraction socket to evaluate its impact on bone density and postoperative pain.

CGF Plug Intervention Group

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Eligibility Criteria

Age20 Years - 50 Years

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64)

You may qualify if:

Systemically healthy patients (ASA I or II)
Age between 20 and 50 years

Sponsors & Collaborators

Cairo University
Otherlead

Study Sites (1)

Cairo University Faculty of Dentistry

Cairo, Egypt

Aziz Taysir HaydarCONTACT+201080823761 ext. +966550484556 Zizoaziz66@gmail.com

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative ComplicationsPathologic ProcessesPathological Conditions, Signs and SymptomsPainNeurologic ManifestationsSigns and Symptoms

Study Officials

Hisham Sayed, Professor
Cairo University
STUDY CHAIR
Abdelmoez Mohamed El-Sharkawy, Associate Professor
Cairo University
STUDY DIRECTOR
Aziz Taysir Haydar
Cairo University
PRINCIPAL INVESTIGATOR

Central Study Contacts

Aziz Taysir Haydar

CONTACT

+201080823761 Zizoaziz66@gmail.com

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NA
Masking: NONE
Purpose: TREATMENT
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Principal Investigator

Study Record Dates

First Submitted

April 15, 2026

First Posted

April 21, 2026

Study Start

September 28, 2026

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Primary Completion

December 1, 2026

Evaluating The Use of CGF Plugs in Fresh Odontectomy Socket.

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Study Arms (1)

CGF Plug Intervention Group

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (2)

Study Arms (1)

CGF Plug Intervention Group

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations