Pancreatic Resection in Fit Octogenarians With Nonmetastatic Pancreatic Cancer

NCT07542782 | Completed

• 1 other identifier: PRONPaC
• Study Type: observational
• Target: 2,048
• Locations: 1 country
• Sites: 1

Brief Summary

This study looks at how different treatment approaches affect survival in older people with pancreatic cancer that has not spread to other parts of the body. In particular, it focuses on patients aged 80 years and older who are still in relatively good general health and able to carry out normal daily activities. Pancreatic cancer is a serious disease, and surgery to remove the tumor is often the only treatment that offers a chance of longer survival. However, older patients are less likely to receive surgery, even if they are otherwise fit. Doctors may hesitate to recommend surgery mainly because of the patient's age, rather than their overall health condition. This study aims to better understand whether surgery can still be beneficial for these older patients. The study also examines the role of additional treatment after surgery, such as chemotherapy. In real-world medical practice, not all patients receive this follow-up treatment, especially older individuals who may have a slower recovery after surgery. This can make it difficult to understand whether such treatments truly improve survival. To answer these questions, the study uses data from a large cancer registry in Germany. It compares patients who had surgery with those who did not, and it also looks at patients who received additional treatment after surgery versus those who did not. Special methods are used to take into account that some patients may not have been able to receive further treatment because they did not recover well enough after surgery. The results of this study are intended to help doctors make better treatment decisions for older patients with pancreatic cancer, focusing more on their overall health and less on age alone.

Conditions

Pancreatic Cancer

Keywords

Pancreatic resection; Octogenarians; Adjuvant therapy; Postoperative Survival; Real-world data; ECOG performance status

Outcome Measures

Primary Outcomes (1)

• Overall Survival

  1 year overall survival after index surgery

Study Arms (2)

Patients younger than 80 years

Procedure: All types of surgical tumor resection procedures with curative intent; Procedure: No surgical resection

Patients between 80 and 89 years

Procedure: All types of surgical tumor resection procedures with curative intent; Procedure: No surgical resection

Interventions

All types of surgical tumor resection procedures with curative intent PROCEDURE

Patients between 80 and 89 years; Patients younger than 80 years

No surgical resection PROCEDURE

Patients between 80 and 89 years; Patients younger than 80 years

Eligibility Criteria

• Age: 18 Years - 89 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All residents of the Federal States Brandenburg and Berlin

You may qualify if:

• Diagnosis of invasive pancreatic carcinoma
• UICC stage I-III
• No distant metastases (M0)
• ECOG performance status 0-1
• Diagnosis between Jan 1, 2017 and Dec 31, 2023
• Residence in Berlin or Brandenburg

You may not qualify if:

• Neuroendocrine tumors
• Sarcomas

Sponsors & Collaborators

• Medizinische Hochschule Brandenburg Theodor Fontane: lead
• Clinical-Epidemiological Cancer Registry Brandenburg Berlin, Cottbus, Germany: collaborator

Study Sites (1)

Medical School Brandenburg

Brandenburg an der Havel, Brandenburg, 14770, Germany

Location

MeSH Terms

Conditions

Pancreatic Neoplasms

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Endocrine Gland Neoplasms; Digestive System Diseases; Pancreatic Diseases; Endocrine System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: April 15, 2026
• First Posted: April 21, 2026
• Study Start: January 1, 2017
• Primary Completion: December 31, 2023
• Study Completion: October 12, 2024
• Last Updated: April 21, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)