NCT07542171|Recruiting
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Sponsor study identifier
observational
400
1 country
3
Study Start
September 3, 2025
Actual (reported)Primary Completion
September 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
December 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
This multicenter study aims to evaluate clinical outcomes and optimize management strategies in patients with early colorectal cancer who undergo non-curative endoscopic resection. Patients with non-curative resection following endoscopic treatment will be enrolled across multiple centers and managed according to real-world clinical decisions, including additional surgery or surveillance. Baseline demographic, endoscopic, and pathological characteristics will be systematically collected. The primary objective is to compare recurrence and survival outcomes between different management strategies. Secondary objectives include identifying prognostic factors associated with recurrence and developing a risk stratification model to guide individualized treatment decisions. All participants will undergo standardized follow-up according to clinical guidelines. This study is expected to provide real-world evidence to refine risk assessment, reduce unnecessary surgery, and improve personalized management for patients with early colorectal cancer after non-curative endoscopic resection.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 3, 2025
Actual (reported)April 14, 2026
Actual (reported)April 21, 2026
Actual (reported)September 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
December 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Recurrence-Free Survival
Up to 2 years
Association Between High-Risk Pathological Factors and Recurrence
Up to 2 years
Patients who underwent additional surgical resection following non-curative endoscopic resection based on pathological risk factors and clinical decision-making.
Patients managed with surveillance after non-curative endoscopic resection, including regular endoscopic and imaging follow-up without additional surgical intervention.
Additional surgical resection performed after non-curative endoscopic resection based on pathological risk factors and clinical indications.
Active surveillance with regular endoscopic and imaging follow-up without additional surgical intervention.
This multicenter cohort study includes adult patients with early colorectal cancer who underwent non-curative endoscopic resection. Participants are stratified into additional surgery and surveillance groups based on post-resection management strategies. Comprehensive clinicopathological characteristics and follow-up data are collected to evaluate recurrence patterns, survival outcomes, and to develop and validate a risk prediction model.
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China
Shenzhen Longgang District People's Hospital
Shenzhen, Guangdong, China
First Submitted
April 14, 2026
First Posted
April 21, 2026
Study Start
September 3, 2025
Actual (reported)Primary Completion
September 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
NYC Heart Follow-Up Study 2010
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The Second Affiliated Hospital of Guangzhou Medical University
Haizhu, Guangzhou, Guangdong, China
Study Completion
December 1, 2028
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
April 21, 2026
Record last verified: 2026-04
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Source: ClinicalTrials.gov.
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