Low Fat-free Mass in Prognosis of People With Chronic Obstructive Pulmonary Disease

NCT07541053 | Completed

• 1 other identifier: MS.24.2.2706
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The effects of low fat-free mass in Prognosis of people with chronic obstructive pulmonary disease (COPD) as regard clinical evaluation using BODE index, GOLD ABE assessment ( Gold 2024 ) functional evaluation using spirometry and 6 min walk test and radiological evaluation by computed chest tomography.

Conditions

Chronic Obstructive Pulmonary Disease (COPD)

Keywords

COPD; FFMI

Outcome Measures

Primary Outcomes (1)

• Fat-free Mass in Chronic Obstructive Pulmonary Disease

  Functional evaluation using 6 min walk test distance (meter)

  6 months

Study Arms (2)

Group A: COPD patients with low FFM

Defined as fat-free mass refers primarily to muscle mass, especially while considering body composition and weight management.

Group B : COPD patients with normal FFM

with normal or high FFM with matched age and sex to the patients group.

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

* Group A: COPD patients with low FFM which is defined as fat-free mass refers primarily to muscle mass, especially while considering body composition and weight management. * Group B: COPD patients with normal FFM with matched age and sex to the patients group.

You may qualify if:

• Were adults aged ≥40 years with a clinical diagnosis of COPD confirmed by spirometry showing post-bronchodilator FEV₁/FVC \<0.70 according to GOLD 2024 criteria

You may not qualify if:

• Exacerbation within the preceding month, active pulmonary infection, physical disability precluding study measurements (e.g., musculoskeletal or neurological disorders), advanced heart failure (NYHA class III-IV), malignancy or hyperthyroidism.

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Mansoura Univeristy Chest Medicine

Al Mansurah, Egypt

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Mohamed Abd ElMoniem

  Lectruer of chest medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of chest medicine

Study Record Dates

• First Submitted: April 15, 2026
• First Posted: April 21, 2026
• Study Start: April 1, 2024
• Primary Completion: October 1, 2024
• Study Completion: April 1, 2025
• Last Updated: April 21, 2026

Record last verified: 2026-04

Locations

EG (1)