Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis

NCT07536204 | Recruiting

• 2 other identifiers: 2023/111231350
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is: Is the JAK1/2 pathway overactivated in periodontitis compared to health? Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.

Conditions

Periodontitis; Periodontal Diseases; Periodontal Inflammation; Gingival Diseases; Periodontal Attachment Loss

Keywords

JAK1; JAK2; Periodontitis; Gingiva; Inflammation

Outcome Measures

Primary Outcomes (1)

• JAK1/2 pathway activation in gingival tissues

  The activation of the JAK1/2 pathway will be evaluated by the phophorilation of JAK1/2 in the gingival tissues determined by western blot. Patients will be categorizied as 0, 1, 2. 0 = no phosphorilation 1. = mild phosphorilation 2. = intense phosphorilation

  Day 1

Study Arms (2)

Healthy gingiva

Adults without gingival inflammation diagnosed by a clinical exam

Periodontits

Adults with periodontitis diagnosed by a clinical exam

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults from the northern area of Santiago, Chile

You may qualify if:

• Adults
• Sistemically healthy

You may not qualify if:

• Active Maliganancy
• History of radiation to the head-neck region
• Chemotherapy or radiation within the last 5 years
• History of hepatitis B/C or HIV infection
• Autoimmune diseases
• Diagnosis of diabetes
• Pregnancy or lactation
• More than 3 hospitalizations over the last 3 years
• Use of systemic antibiotics over the last 3 months
• Use of systemic corticosteroids or immunosuppressants over the last 3 months
• Use of cytokine therapy over the last 3 months
• Use of large doses of pre/probiotic supplements over the last 3 months
• Smoke more than 10 cigarettes per day

Sponsors & Collaborators

• University of Chile: lead

Study Sites (1)

Faculty of Dentistry, University of Chile

Santiago, Metropolitan Region, Chile

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Gingival tissue biopsies form healty and periodontitis patients

MeSH Terms

Conditions

Periodontitis; Periodontal Diseases; Gingival Diseases; Periodontal Attachment Loss; Inflammation

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Periodontal Atrophy; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Nicolas Dutzan, DDS, PhD

CONTACT

+56934037995; ndutzan@uchile.cl

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 19, 2026
• First Posted: April 17, 2026
• Study Start: June 1, 2023
• Primary Completion (Estimated): March 31, 2027
• Study Completion (Estimated): March 31, 2027
• Last Updated: April 17, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

CL (1)