Aldosterone Identifies a High-Risk Recurrent Phenotype in Severe Hypertension

NCT07535814 | Completed

• 1 other identifier: VATAHTA
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

Acute severe hypertension is a common and heterogeneous clinical condition associated with significant short-term morbidity and health care utilization. Despite its frequency, underlying pathophysiological mechanisms remain poorly characterized, particularly regarding the role of aldosterone dysregulation beyond classical primary aldosteronism. The VATAHTA Acute Study is an observational cohort study designed to evaluate the association between aldosterone levels, renin profiles, and clinical outcomes in patients presenting with acute severe hypertension requiring hospital admission. The study aims to characterize a potential spectrum of aldosterone dysregulation and its relationship with short-term clinical severity, including length of hospital stay, target organ damage, and cardiovascular events. By integrating clinical, biochemical, and outcome data, this study seeks to improve the understanding of pathophysiological phenotypes in acute severe hypertension and identify potential targets for risk stratification and future therapeutic strategies.

Conditions

Acute Severe Hypertension

Keywords

Aldosterone; Acute Severe Hypertension; Cardiovascular Risk

Outcome Measures

Primary Outcomes (1)

• Length of hospital stay

  Length of hospital stay (LOS), measured in days, defined as the time from hospital admission to discharge, will be used as a marker of short-term clinical severity. The association between plasma aldosterone levels and LOS will be evaluated using multivariable models adjusted for relevant clinical and biochemical confounders.

  rom hospital admission to discharge (index hospitalization), an average of 36 months

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients admitted to hospital due to acute severe hypertension, identified from institutional databases. The study population includes individuals with available biochemical assessment of the renin-angiotensin-aldosterone system at admission, allowing evaluation of aldosterone-related pathophysiological phenotypes and their association with short-term clinical outcomes.

You may qualify if:

• Adults aged ≥18 years Hospital admission due to acute severe hypertension, defined as systolic blood pressure ≥180 mmHg and/or diastolic blood pressure ≥120 mmHg requiring in-hospital management Availability of plasma aldosterone and renin measurements at hospital admission or within the first 24 hours Availability of key clinical and laboratory data, including blood pressure, renal function, and serum potassium levels

Sponsors & Collaborators

• School of Medicine. National University of Cuyo: lead
• Hospiral Español de Mendoza: collaborator

Study Sites (1)

Laura Grazini

Godoy Cruz, Mendoza Province, 5501, Argentina

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Phisiopathology. School of Medicine. National University of Cuyo

Study Record Dates

• First Submitted: April 5, 2026
• First Posted: April 17, 2026
• Study Start: March 1, 2022
• Primary Completion: December 20, 2025
• Study Completion: April 1, 2026
• Last Updated: April 17, 2026

Record last verified: 2026-04

Locations

AR (1)