Periodontal Gel in NSPT

NCT07534449 | Completed

• 1 other identifier: 1956/2024
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective case series included patients with stage II/III periodontitis treated with non-surgical periodontal therapy combined with a topical postbiotic gel. Clinical parameters (PD, CAL, BoP, PI) were recorded at baseline and after 8 weeks. Patients also applied the gel and a specific toothpaste at home, and outcomes were evaluated through clinical measurements and patient-reported feedback.

Conditions

Periodontal Diseases; Periodontal Disease, Stage 3

Keywords

Periodontal Disease; NSPT; Scaling and Root Planing

Outcome Measures

Primary Outcomes (2)

• Probing depth

  Probing Depth (PD), measured in millimeters (mm) using a PCP 15 UNC periodontal probe. PD represents the distance from the gingival margin to the base of the periodontal pocket. The measurement range is from 0 to 15 mm. Higher values indicate deeper periodontal pockets and a worse periodontal condition.

  From enrollment to the end of treatment at 8 weeks

• Clinical Attachment Level (CAL)

  Clinical Attachment Level (CAL), measured in millimeters (mm) using a PCP 15 UNC periodontal probe. CAL represents the distance from the cemento-enamel junction (CEJ) to the base of the periodontal pocket. The measurement range is from 0 to 15 mm. Higher values indicate greater attachment loss and a worse periodontal outcome.

  From enrollment to the end of treatment at 8 weeks

Secondary Outcomes (3)

• Full Mouth Bleeding Score (FMBS)

  From enrollment to the end of treatment at 8 weeks

• Full Mouth Plaque Score (FMPS)

  From enrollment to the end of treatment at 8 weeks

• Patient Satisfaction (Questionnaire)

  From enrollment to the end of treatment at 8 weeks

Study Arms (1)

Periodontal Gel + NSPT

EXPERIMENTAL

Adjunctive use of a gel after NSPT

Other: Periodontal Gel as an Adjunct to NSPT

Interventions

Periodontal Gel as an Adjunct to NSPT OTHER

Immediately after NSPT all patients were instructed to pass the interdental brush with the gel in the interdental space and with the finger on the gums.

Periodontal Gel + NSPT

Eligibility Criteria

• Age: 30 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients with Stage II and Stage III periodontal disease
• Subjects aged between 30 and 70 years
• Non-smokers or light smokers (\<10 cigarettes/day)

You may not qualify if:

• Patients with Stage I or Stage IV periodontal disease
• Current heavy smokers (≥10 cigarettes/day)
• HbA1c \> 7%
• ASA \> III
• Patients alredy using the study products

Sponsors & Collaborators

• University of Roma La Sapienza: lead

Study Sites (1)

Sapienza

Roma, RM, 00161, Italy

Location

Related Publications (1)

• Butera, A. P. (2022). Domiciliary use of chlorhexidine vs. postbiotic gels in patients with peri-implant mucositis: a split-mouth randomized clinical trial. Applied Sciences.

  BACKGROUND

MeSH Terms

Conditions

Periodontal Diseases

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor, MD, pHd

Study Record Dates

• First Submitted: April 9, 2026
• First Posted: April 16, 2026
• Study Start: May 1, 2022
• Primary Completion: November 1, 2024
• Study Completion: March 1, 2025
• Last Updated: April 16, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)