NCT07532603

Brief Summary

This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with lichen planopilaris

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
342

participants targeted

Target at P75+ for phase_2

Timeline
36mo left

Started Mar 2026

Typical duration for phase_2

Geographic Reach
4 countries

61 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress11%
Mar 2026Jul 2029

Study Start

First participant enrolled

March 19, 2026

Completed
15 days until next milestone

First Submitted

Initial submission to the registry

April 3, 2026

Completed
13 days until next milestone

First Posted

Study publicly available on registry

April 16, 2026

Completed
2.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2028

Expected
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 31, 2029

Last Updated

July 8, 2026

Status Verified

July 1, 2026

Enrollment Period

2.8 years

First QC Date

April 3, 2026

Last Update Submit

July 6, 2026

Conditions

Lichen Planopilaris

Keywords

brepocitiniblichen planopilaris

Outcome Measures

Primary Outcomes (1)

  • Proportion of participants achieving IGA score 0/1 and ≥ 2-step reduction from baseline at Week 24

    Week 24

Secondary Outcomes (1)

  • Change from baseline in LPP symptom numerical rating scale scores at Week 24

    Week 24

Study Arms (2)

Brepocitinib Dose Level 1

EXPERIMENTAL
Drug: Oral Brepocitinib

Placebo

PLACEBO COMPARATOR
Drug: Placebo

Interventions

Oral BrepocitinibDRUG

Oral

Brepocitinib Dose Level 1
PlaceboDRUG

Oral

Placebo

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age ≥ 18 years
  • Scalp biopsy consistent with LPP
  • Active and symptomatic LPP at screening and baseline-
  • Weight \> 40 kg to \< 130 kg with BMI ≤ 45 kg/m2

You may not qualify if:

  • History of: Lymphoproliferative disorder; Active malignancy; History of cancer within 5 years prior to baseline (exceptions for basal cell carcinoma, squamous cell carcinoma, ductal carcinoma in situ of the breast, carcinoma in situ of the uterine cervix, or thyroid cancer).
  • High risk of thrombosis or cardiovascular disease
  • High risk of herpes zoster
  • Active or recent infection

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (61)

Clinical Trial Site

Birmingham, Alabama, 35244, United States

RECRUITING

Clinical Trial Site

Phoenix, Arizona, 85006, United States

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Clinical Trial Site

Scottsdale, Arizona, 85259, United States

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Clinical Trial Site

Irvine, California, 92617, United States

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Clinical Trial Site

Oakland, California, 94611, United States

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Clinical Trial Site

Sacramento, California, 95823, United States

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Clinical Trial Site

San Francisco, California, 94115, United States

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Clinical Trial Site

Denver, Colorado, 80237, United States

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Clinical Trial Site

Farmington, Connecticut, 06032, United States

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Clinical Trial Site

New Haven, Connecticut, 06519, United States

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Clinical Trial Site

Miami, Florida, 33136, United States

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Clinical Trial Site

Chicago, Illinois, 60611, United States

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Clinical Trial Site

Skokie, Illinois, 60077, United States

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Clinical Trial Site

Clarksville, Indiana, 47129, United States

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Clinical Trial Site

Indianapolis, Indiana, 46250, United States

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Clinical Trial Site

Leawood, Kansas, 66211, United States

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Clinical Trial Site

Louisville, Kentucky, 40241, United States

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Clinical Trial Site

Boston, Massachusetts, 02115, United States

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Clinical Trial Site

Burlington, Massachusetts, 01805, United States

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Clinical Trial Site

Ann Arbor, Michigan, 48103, United States

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Clinical Trial Site

Ann Arbor, Michigan, 48109, United States

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Clinical Trial Site

Medina, Minnesota, 55340, United States

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Clinical Trial Site

Minneapolis, Minnesota, 55455, United States

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Clinical Trial Site

Kansas City, Missouri, 66103, United States

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Clinical Trial Site

Lee's Summit, Missouri, 64064, United States

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Clinical Trial Site

Lebanon, New Hampshire, 03766, United States

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Clinical Trial Site

New Hyde Park, New York, 11042, United States

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Clinical Trial Site

New York, New York, 10451, United States

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Clinical Trial Site

Durham, North Carolina, 27713, United States

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Clinical Trial Site

Cleveland, Ohio, 44195, United States

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Clinical Trial Site

Columbus, Ohio, 43213, United States

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Clinical Trial Site

Medina, Ohio, 44256, United States

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Clinical Trial Site

Portland, Oregon, 97210, United States

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Clinical Trial Site

Philadelphia, Pennsylvania, 19104, United States

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Clinical Trial Site

Charleston, South Carolina, 29425, United States

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Clinical Trial Site

Murfreesboro, Tennessee, 37128, United States

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Clinical Trial Site

Smyrna, Tennessee, 37167, United States

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Clinical Trial Site

Austin, Texas, 78613, United States

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Clinical Trial Site

Austin, Texas, 78660, United States

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Clinical Trial Site

Cedar Park, Texas, 78613, United States

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Clinical Trial Site

Prosper, Texas, 75078, United States

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Clinical Trial Site

Tyler, Texas, 75703, United States

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Clinical Trial Site

Murray, Utah, 84107, United States

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Clinical Trial Site

Norfolk, Virginia, 23502, United States

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Clinical Trial Site

Richmond, Virginia, 23235, United States

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Clinical Trial Site

Roanoke, Virginia, 24016, United States

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Clinical Trial Site

Mill Creek, Washington, 98012, United States

RECRUITING

Clinical Trial Site

Adelaide, 5074, Australia

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Clinical Trial Site

Perth, 6018, Australia

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Clinical Trial Site

Sydney, 2217, Australia

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Clinical Trial Site

Edmonton, Alberta, T6G1C3, Canada

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Clinical Trial Site

Guelph, Ontario, N1L0B7, Canada

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Clinical Trial Site

London, Ontario, M5M3Z8, Canada

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Clinical Trial Site

Toronto, Ontario, L4B1A5, Canada

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Clinical Trial Site

Toronto, Ontario, N6H5L4, Canada

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Clinical Trial Site

Salford, Manchester, M68HD, United Kingdom

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Clinical Trial Site

Glasgow, Scotland, G312ER, United Kingdom

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Clinical Trial Site

Brighton, BN21ES, United Kingdom

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Clinical Trial Site

London, SE19RT, United Kingdom

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Clinical Trial Site

London, SW109NH, United Kingdom

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Clinical Trial Site

Wrexham, LL7YP, United Kingdom

RECRUITING

MeSH Terms

Conditions

Lichen Planus

Condition Hierarchy (Ancestors)

Lichenoid EruptionsSkin Diseases, PapulosquamousSkin DiseasesSkin and Connective Tissue Diseases

Central Study Contacts

Clinical Trial Administrator

CONTACT

(212) 634-9743clinicaltrials@priovant.com

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

April 3, 2026

First Posted

April 16, 2026

Study Start

March 19, 2026

Primary Completion (Estimated)

December 31, 2028

Study Completion (Estimated)

July 31, 2029

Last Updated

July 8, 2026

Record last verified: 2026-07

Data Sharing

IPD Sharing
Will not share

Locations

AU(3)GB(6)CA(5)US(47)