Autologous Blood Products in Ridge Preservation

NCT07530471 | Active Not Recruiting

• 2 other identifiers: OGU-EC-07-252024-KAEK-15
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled clinical trial aims to evaluate the clinical, radiographic, and ultrasonographic outcomes of alveolar ridge preservation using autologous blood products following tooth extraction. After tooth extraction, dimensional changes occur in both hard and soft tissues, which may negatively affect future implant or prosthetic treatments. This study investigates whether the application of Titanium Platelet-Rich Fibrin (T-PRF), combined with injectable Platelet-Rich Fibrin (i-PRF), can improve healing and reduce tissue changes. In this study, tooth extraction will be performed under local anesthesia using minimally invasive techniques. Autologous blood will be collected from the patient and processed by centrifugation to obtain T-PRF and i-PRF. The prepared materials will be applied to the extraction socket and stabilized with sutures. Healing will be monitored through clinical examinations, radiographic imaging, and ultrasonographic evaluations over a 6-month follow-up period. Possible risks include pain, bleeding, infection, and temporary discomfort, all of which are manageable with standard clinical care. The study is expected to contribute to the development of biologically based, minimally invasive treatment approaches that enhance tissue healing and support future dental treatments.

Conditions

Ridge Preservation

Keywords

Ridge Preservation; T-PRF; i-PRF; T-PRF Plus

Outcome Measures

Primary Outcomes (1)

• Horizontal Bone Width Change (CBCT Analysis)

  Evaluation of horizontal bone width in millimeters at standardized levels (1 mm, 3 mm, and 5 mm from the alveolar crest) using CBCT at baseline (immediately after extraction) and 6 months

  6 month

Study Arms (2)

control

NO INTERVENTION

test

ACTIVE COMPARATOR

Procedure: Autologous Titanium Platelet-Rich Fibrin with Injectable PRF Application

Interventions

Autologous Titanium Platelet-Rich Fibrin with Injectable PRF Application PROCEDURE

Following atraumatic tooth extraction under local anesthesia, autologous blood will be collected from the patient. Titanium platelet-rich fibrin (T-PRF) will be prepared by centrifugation of blood in titanium tubes, and injectable platelet-rich fibrin (i-PRF) will be obtained using a low-speed centrifugation protocol. The prepared i-PRF will be injected into the T-PRF membrane to create a combined autologous fibrin construct. This material will then be placed into the extraction socket to support clot stability and tissue regeneration, and the site will be sutured for stabilization. This approach combines the dense fibrin structure of T-PRF with the biological activity of i-PRF, aiming to enhance angiogenesis, soft and hard tissue healing, and preservation of alveolar ridge dimensions.

test

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Systemically healthy individuals with no medical conditions that could interfere with periodontal treatment, tooth extraction, or wound healing
• Absence of systemic diseases affecting blood coagulation and no use of anticoagulant medications
• No history of blood-borne infectious diseases
• Non-smokers
• Age ≥18 years
• Patients requiring extraction of a single-rooted tooth in the maxilla or mandible
• Availability of a pre-existing CBCT scan of the planned extraction site
• Extraction site suitable for implant placement

You may not qualify if:

• Presence of systemic diseases that may affect periodontal treatment, tooth extraction, wound healing, or increase the risk of complications
• Presence of bleeding or coagulation disorders, or use of anticoagulant therapy
• Presence of blood-borne infectious diseases
• Smoking habit
• Age \<18 years
• Psychological or mental conditions that may affect compliance with treatment or study participation
• Extraction sites not suitable for implant placement
• History of previous surgical intervention or compromised healing in the extraction site
• Pregnancy

Sponsors & Collaborators

• Çanakkale Onsekiz Mart University: lead

Study Sites (1)

Çanakkale Onsekiz Mart University

Çanakkale, Turkey (Türkiye)

Location

Related Publications (1)

• Araujo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005 Feb;32(2):212-8. doi: 10.1111/j.1600-051X.2005.00642.x.

  PMID: 15691354 BACKGROUND

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: April 1, 2026
• First Posted: April 15, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): January 1, 2027
• Last Updated: April 15, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)