Efficacy of Periarticular Vasoconstrictor Infiltration (PVI) in Reducing Bleeding and Postoperative Pain in Lumbar Fusion Surgery

NCT07530237 | Active Not Recruiting DMC

• 1 other identifier: IIBSP-EIP-2025-213
• Study Type: observational
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective observational study evaluates the efficacy of periarticular vasoconstrictor infiltration (PVI) in reducing intraoperative bleeding and postoperative pain in adult patients undergoing lumbar fusion surgery at Hospital de la Santa Creu i Sant Pau (Barcelona, Spain) from November 2024 to October 2025. PVI, introduced recently as an alternative to erector spinae plane (ESP) block, involves ultrasound-guided infiltration of local anesthetic with epinephrine in deep and superficial periarticular planes before surgery. The study includes all consecutive cases meeting inclusion criteria (lumbar fusion in adults), excluding incomplete records (expected n=25).

Conditions

Intraoperative Bleeding in Lumbar Spine Surgery; Postoperative Pain in Lumbar Spine Surgery

Keywords

lumbar fusion; Periarticular vasoconstrictor infiltration (PVI); Bleeding; Postoperative pain; Erector spinae block (ESP); Regional anesthesia

Outcome Measures

Primary Outcomes (2)

• Intraoperative blood loss

  Total volume aspirated (mL) from surgical suction, minus irrigation volume

  Perioperative

• Postoperative pain intensity

  Numeric Verbal Scale (0-10) at 24 hours

  up to 24 hours

Secondary Outcomes (6)

• Postoperative opioid consumption

  up to 24 hours

• Opioid-related adverse effects

  up to 24 hours

• Drain output

  Perioperative

• Need for blood transfusion

  Perioperative

• Length of hospital stay

  Perioperative

Study Arms (1)

PVI Lumbar Fusion Patients

Patients treated with PVI during lumbar fusion surgery

Other: Periarticular Vasoconstrictor Infiltration

Interventions

Periarticular Vasoconstrictor Infiltration OTHER

Ultrasound-guided infiltration of local anesthetic and epinephrine in deep and superficial periarticular planes before lumbar fusion surgery, as part of routine clinical care.

PVI Lumbar Fusion Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients (18-90 years) undergoing elective lumbar fusion surgery for degenerative disc disease, spondylolisthesis, or lumbar stenosis at Hospital de la Santa Creu i Sant Pau (Barcelona). Typical characteristics: mixed gender, ASA I-III, comorbidities common in orthopedic spine population.

You may qualify if:

• Adult patients undergoing lumbar fusion surgery who received PVI between November 2024-October 2025 at Hospital de Sant Pau

You may not qualify if:

• Incomplete surgeries, incomplete clinical data, or poor quality anesthesia records.

Sponsors & Collaborators

• Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau: lead

Study Sites (1)

Hospital de La Santa Creu I Sant Pau

Barcelona, BARCELONA, 08025, Spain

Location

MeSH Terms

Conditions

Hemorrhage; Pain, Postoperative

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Postoperative Complications; Pain; Neurologic Manifestations; Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiologist specialized in Regional and Orthopedic Anesthesia at Hospital de Sant Pau, Barcelona"

Study Record Dates

• First Submitted: March 23, 2026
• First Posted: April 15, 2026
• Study Start: March 12, 2026
• Primary Completion: April 12, 2026
• Study Completion: April 30, 2026
• Last Updated: April 15, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)