Prospective RegIstry for Oncologic Reirradiation (PRIOR-DK)

NCT07528339 | Not Yet Recruiting

• 1 other identifier: PRIOR
• Study Type: observational
• Target: 500
• Locations: 0 countries
• Sites: N/A

Brief Summary

The study aims to provide a setup for collecting radiotherapy-related toxicity data, loco-regional control, and overall survival data for all Danish cancer patients undergoing reirradiation with high dose intention or with the aim of local tumour control; with the ultimate aim of providing safe reirradiation to a larger group of patients. To build a reirradiation cohort database for future research

Conditions

Radiotherapy Side Effect

Outcome Measures

Primary Outcomes (1)

• Side effects

  CTCAE side effects

  5 years

Study Arms (1)

Reirradiation

All patients treated with reirradiation with the aim of local control

Radiation: Reirradiation

Interventions

Reirradiation RADIATION

reirradiation with all available modalities can be included

Reirradiation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

No guidelines are provided on the selection of patients for high dose reirradiation. All patients are eligible for the database if treated with reirradiation with the aim of local control.

You may qualify if:

• High dose reirradiation (reirradiation type I or II or repeat organ irradiation delivered with the aim of local control)
• Read Danish (for questionnaires + patient information)
• Life expectancy due to age and co-morbidity of ≥6 months.
• The general condition must be sufficient to tolerate persistent significant side effects
• Histological or imaging verified loco-regional recurrence, solitary oligo metastasis or new primary
• Age ≥18 years
• Signed informed consent, updated annually
• Expected follow up physical, by video, by phone or likely contact at a relevant oncological department

You may not qualify if:

• The primary and reirradiation treatments may not be quasi-simultaneous (i.e. the two treatments should be planned independently)
• Inability to attend full course of radiotherapy
• Purpose of radiotherapy is ONLY palliation of symptoms

Sponsors & Collaborators

• University of Aarhus: lead

MeSH Terms

Conditions

Radiation Injuries

Interventions

Re-Irradiation

Condition Hierarchy (Ancestors)

Wounds and Injuries

Intervention Hierarchy (Ancestors)

Radiotherapy; Therapeutics; Retreatment

Central Study Contacts

Hanna R Mortensen, PhD, MD

CONTACT

92432382; hanna.mortensen@auh.rm.dk

Camilla JS Kronborg, PhD, MD

CONTACT

cam.kro@auh.rm.dk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 7, 2026
• First Posted: April 14, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): March 31, 2032
• Study Completion (Estimated): March 31, 2037
• Last Updated: April 14, 2026

Record last verified: 2026-02