Comparison of the Analgesic Efficacy of Adductor Canal Block and Combined Adductor Canal Block Plus IPACK Block in Knee Surgery

NCT07526831 | Recruiting

• 1 other identifier: 2026\115
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 2

Brief Summary

To evaluate the effectiveness of Adductor Canal Block and combined Adductor Canal plus IPACK block in reducing postoperative pain and analgesic requirements in patients undergoing knee surgery.

Conditions

Knee Arthroplasty, Total

Keywords

Postoperative analgesia, Ultrasound, IPACK block, Adductor canal block, Total knee arthroplasty

Outcome Measures

Primary Outcomes (2)

• opioid consumption

  In the recovery room, all patients will given a patient- controlled analgesia device containing morphine 0.5 mg/ml, set to deliver a 1mg bolus dose of morphine with an 15 min lockout time and 4 mg 1 h limit.Total morphine consumption during the 24 hours postoperative period will recorded at 5 times intervals ( 2, 4, 6, 12, 24 hours).

  24 hours after surgery

• Verbal analog Pain Scores on rest and movement

  A Research assistant, blinded to the group allocation, interviewed patients and collected data at 5 times intervals ( 2, 4, 6, 12, 24, hours) in the 24 hours postoperatively. Patients were asked to rate their pain using verbal analog scale, where 0= no pain and 10= worst pain possible.

  24 hours after surgery

Secondary Outcomes (1)

• incidences of adverse effects (like nausea and vomiting)

  24 hours after surgery

Study Arms (2)

Adductor canal block group(ACB)

Patients in the ACB group (Group I) will receive a single-shot adductor canal block under ultrasound guidance bupivacaine administered preoperatively.

Procedure: Adductor Canal Block Group (Group I)

Adductor canal + iPACK block group(ACB+IPACK)

Patients in the ACB + iPACK group (Group II) will receive a single-shot adductor canal block combined with an infiltration between the popliteal artery and the capsule of the knee (iPACK) under ultrasound guidance bupivacaine.

Procedure: Adductor Canal + iPACK Block Group (Group II)"

Interventions

Adductor Canal Block Group (Group I) PROCEDURE

All patients in Group I will receive a preoperative adductor canal block. In all groups, an intravenous patient-controlled analgesia device containing morphine will be administered for postoperative pain management.

Adductor canal block group(ACB)

Adductor Canal + iPACK Block Group (Group II)" PROCEDURE

All patients in Group II will receive a preoperative adductor canal block combined with an iPACK block. Postoperatively, all patients in both groups will be provided with intravenous patient-controlled analgesia containing morphine for pain management.

Adductor canal + iPACK block group(ACB+IPACK)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients aged ≥18 years, classified as ASA physical status I-III, scheduled to undergo total knee arthroplasty.

You may qualify if:

• ASA (American Society of Anesthesiologists) I- ASA II-ASA III Patients

You may not qualify if:

• history of allergy to the study medication
• refusal to participate

Sponsors & Collaborators

• TC Erciyes University: lead

Study Sites (2)

Sibel Pehlivan

Kayseri, Talas, 38090, Turkey (Türkiye)

RECRUITING

Sibel Seckin Pehlivan

Kayseri, 38039, Turkey (Türkiye)

RECRUITING

Related Publications (2)

• Shoni M, Samineni AV, Salavati S, Mikkilineni N, Wang A, Abdeen A, Freccero D. Combined Single-Shot Infiltration Between the Popliteal Artery and Capsule of the Knee and Adductor Canal Block With Bupivacaine, Dexmedetomidine, and Dexamethasone for Total Knee Arthroplasty: A Propensity-Matched Analysis. Arthroplast Today. 2023 Dec 28;25:101292. doi: 10.1016/j.artd.2023.101292. eCollection 2024 Feb.

  PMID: 38235397 RESULT

• Mariano ER, Kim TE, Wagner MJ, Funck N, Harrison TK, Walters T, Giori N, Woolson S, Ganaway T, Howard SK. A randomized comparison of proximal and distal ultrasound-guided adductor canal catheter insertion sites for knee arthroplasty. J Ultrasound Med. 2014 Sep;33(9):1653-62. doi: 10.7863/ultra.33.9.1653.

  PMID: 25154949 RESULT

Related Links

• Combined Single-Shot Infiltration Between the Popliteal Artery and Capsule of the Knee and Adductor Canal Block With Bupivacaine, Dexmedetomidine, and Dexamethasone for Total Knee Arthroplasty: A Propensity-Matched Analysis

Study Officials

• Sibel Pehlivan

  Erciyes Üniversitesi

  STUDY DIRECTOR

Central Study Contacts

Sibel Pehlivan, DR

CONTACT

0905052532919; Sibelpehlivan@erciyes.edu.tr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Teaching Assistant

Study Record Dates

• First Submitted: April 7, 2026
• First Posted: April 13, 2026
• Study Start: April 15, 2026
• Primary Completion (Estimated): April 15, 2028
• Study Completion (Estimated): May 1, 2028
• Last Updated: April 13, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
• Time Frame: Data will be available within 12 months of study completion
• Access Criteria: Data accept requests will be reviewed by an external independent Review Panel.Requesters will be required to sign a Data Access Agreement.

Locations

TU (2)