NCT07526753

Brief Summary

The purpose of this study is to assess the efficacy of ESWT, EPAT, EMTT and the combination of these therapies in treating patients with lower extremity soft tissue, cartilage, and bone injuries.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
108mo left

Started Mar 2026

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress2%
Mar 2026Apr 2035

Study Start

First participant enrolled

March 15, 2026

Completed
22 days until next milestone

First Submitted

Initial submission to the registry

April 6, 2026

Completed
7 days until next milestone

First Posted

Study publicly available on registry

April 13, 2026

Completed
9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2035

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2035

Last Updated

April 13, 2026

Status Verified

April 1, 2026

Enrollment Period

9.1 years

First QC Date

April 6, 2026

Last Update Submit

April 6, 2026

Conditions

Musculoskeletal Injury

Outcome Measures

Primary Outcomes (1)

  • VAS

    initial, 6weeks, 3 months, 6 months, 1 year

Secondary Outcomes (1)

  • FAAM

    baseline, 6 week, 3 month, 6 month 1 year

Study Arms (4)

shock wave only

EXPERIMENTAL
Device: Shock wave

shock wave + radial pressure wave

EXPERIMENTAL
Device: Shock waveDevice: Radial pressure waves

EMTT

EXPERIMENTAL

EMTT

Device: Electromagnetic transduction therapy (EMTT)

shock wave + EMTT

EXPERIMENTAL
Device: Shock waveDevice: Electromagnetic transduction therapy (EMTT)

Interventions

Shock waveDEVICE

shockwave

shock wave + EMTTshock wave + radial pressure waveshock wave only
Radial pressure wavesDEVICE

Pressure waves

shock wave + radial pressure wave
Electromagnetic transduction therapy (EMTT)DEVICE

EMTT

EMTTshock wave + EMTT

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Men and women \> 18 with lower extremity musculoskeletal injury confirmed by physician

You may not qualify if:

  • All devices: Patients with active cancer or who may be pregnant.
  • For EMTT only, patients with shrapnel, metal in the body, pacemaker, or non-MRI compatible implantable devices.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Location

Related Links

MeSH Terms

Interventions

Extracorporeal Shockwave Therapy

Intervention Hierarchy (Ancestors)

Ultrasonic TherapyDiathermyHyperthermia, InducedTherapeuticsPhysical Therapy ModalitiesRehabilitation

Study Officials

  • Elizabeth Bondi

    Mayo Clinic

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

April 6, 2026

First Posted

April 13, 2026

Study Start

March 15, 2026

Primary Completion (Estimated)

April 1, 2035

Study Completion (Estimated)

April 1, 2035

Last Updated

April 13, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will not share

Locations

US(1)