Effect of Sciatic Nerve Mobilization on Lower Extremity Pain Perception

NCT07525895 | Enrolling By Invitation

• 1 other identifier: FenerbahceUniver
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled study aims to investigate the effect of sciatic nerve mobilization on pain perception in lower extremity peripheral nerves, specifically the tibial and common peroneal nerves. The study will be conducted in university students at Fenerbahçe University. Participants will be randomly assigned to either an intervention group or a control group. Pressure pain threshold (PPT) will be measured using a pressure algometer at standardized anatomical points over the tibial and common peroneal nerves before and after the intervention period. Demographic and clinical information, including age, sex, height, weight, dominant lower extremity, physical activity level, history of lower extremity injury or surgery, neurological or systemic disease, and regular medication use, will also be recorded. Participants in the intervention group will receive a standardized sciatic nerve mobilization protocol consisting of sliding-type neurodynamic mobilization performed in the supine position, including components of hip flexion, knee extension, and ankle dorsiflexion/plantarflexion in a rhythmic sequence. No intervention will be applied to the control group. The primary purpose of the study is to determine whether sciatic nerve mobilization changes pressure pain threshold values in the tibial and common peroneal nerves compared with no intervention.

Conditions

Sciatic Nerve; Lower Extremity Pain

Keywords

Sciatic nerve mobilization; Pressure pain threshold; Neurodynamic mobilization; Peripheral nerve mechanosensitivity

Outcome Measures

Primary Outcomes (2)

• Pressure Pain Threshold of the Tibial Nerve

  Pressure pain threshold of the tibial nerve will be assessed using a pressure algometer at a standardized anatomical point in the popliteal fossa. The algometer probe will be placed perpendicular to the skin, and pressure will be gradually increased until the participant first reports pain. The recorded value will be used as the pressure pain threshold.

  Before intervention and immediately after intervention

• Pressure Pain Threshold of the Common Peroneal Nerve

  Pressure pain threshold of the common peroneal nerve will be assessed using a pressure algometer at a standardized anatomical point around the fibular head/neck region. The algometer probe will be placed perpendicular to the skin, and pressure will be gradually increased until the participant first reports pain. The recorded value will be used as the pressure pain threshold.

  Before intervention and immediately after intervention

Study Arms (2)

Sciatic Nerve Mobilization Group

EXPERIMENTAL

Participants in this group will receive a standardized sliding-type sciatic nerve mobilization. Pressure pain threshold of the tibial and common peroneal nerves will be measured before and after the intervention.

Other: Sciatic Nerve Mobilization

Control Group

NO INTERVENTION

Participants in this group will receive no intervention. Pressure pain threshold of the tibial and common peroneal nerves will be measured before and after the study procedure.

Interventions

Sciatic Nerve Mobilization OTHER

A standardized sliding-type sciatic nerve mobilization will be applied in the supine position. The technique includes coordinated hip flexion, knee extension, and ankle dorsiflexion/plantarflexion movements to produce a sliding effect on the sciatic nerve.

Sciatic Nerve Mobilization Group

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Aged 18 to 30 years
• Being a student at Fenerbahçe University
• No history of major trauma or surgery in the lower extremity within the last 6 months
• Voluntarily agreeing to participate in the study and signing the informed consent form

You may not qualify if:

• History of neurological disease
• History of lower extremity peripheral nerve injury
• Having undergone lower extremity surgery within the last 6 months
• Regular use of analgesic or muscle relaxant medications
• Pregnancy
• Presence of any systemic disease that may interfere with the assessment or intervention procedures

Sponsors & Collaborators

• Fenerbahce University: lead

Study Sites (1)

Fenerbahçe University

Istanbul, Ataşehir, 34758, Turkey (Türkiye)

Location

Study Officials

• Sümeyye Akçay, Asst. Prof.

  Fenerbahçe University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: The outcome assessor measuring pressure pain threshold values will be blinded to group allocation. The investigator delivering the intervention and the participants will not be blinded.
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Asst. Prof.

Model Details: Participants will be randomly assigned to one of two parallel groups: an intervention group receiving sciatic nerve mobilization or a control group receiving no intervention. Pressure pain threshold measurements of the tibial and common peroneal nerves will be obtained before and after the study procedure in both groups.

Study Record Dates

• First Submitted: April 6, 2026
• First Posted: April 13, 2026
• Study Start: March 20, 2026
• Primary Completion: May 1, 2026
• Study Completion: May 1, 2026
• Last Updated: April 27, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)