Walking Fatigability,Saptiotemporal Gait Parameters and Falling in MS Patients

NCT07524556 | Not Yet Recruiting

• 2 other identifiers: MS-WF-GAIT-FALL-2026P.T.REC/012/006167
• Study Type: observational
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study aims to investigate the relationship between walking fatigability, changes in spatiotemporal gait parameters, and risk of falling in individuals with multiple sclerosis (MS). Participants will be divided into two groups: those with walking fatigability and those without. Each participant will undergo functional tests to detect deterioration in patiotemoral gait parameters and risk of falling . The results of this study will help understand how walking fatigability affects gait and fall risk in MS, providing insights for rehabilitation strategies.

Conditions

Multiple Sclerosis

Keywords

MS; walking fatigability; gait parameters; risk of falling

Outcome Measures

Primary Outcomes (4)

• Distance walking index

  measurd as a decline in walking distance between first and last minute more than 10%

  Baseline

• Spatiotemporal Gait Parameters

  includes step length in meter(m) , gait velocity in meter per secound(m/s) and double time support in secounds(s) measured using gait analysis tool ( kinovea software)

  Baseline

• Risk of Falling

  Assessed using fall efficacy scale- international and timed up and go test measured in secounds(s)

  Baseline

• precived fatigue

  assessed by modified fatigue impact scale

  Baseline

Study Arms (2)

G1: fatiged patients

patients with Multiple Sclerosis showing walking fatigability. They underwent spatiotemporal gait assessment and fatigability testing

G2: non fatiged patients

patients with Multiple Sclerosis without walking fatigability. They underwent spatiotemporal gait assessment and fatigability testing

Eligibility Criteria

• Age: 20 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Sixty-two RRMS will be recruited in this study from multiple sclerosis specialized clinic in the Neurology department, Faculty of Medicine, Alexandria University. The patients will be diagnosed and referred to by a neurologist participants aged from 20 to 40 years with a confirmed diagnosis of multiple sclerosis (based on McDonald criteria). Ambulatory for at least 6 minutes, without the use of assistive devices.EDSS score between 2.0 and 5.0.no relapse within 1 month prior to participation

You may qualify if:

• Sixty-two RRMS patients from both sexes.
• Aged from 20 to 40 years with a confirmed diagnosis of multiple sclerosis (based on McDonald criteria).
• Ambulatory for at least 6 minutes, without the use of assistive devices.
• EDSS score between 2.0 and 5.0.
• no relapse within 1 month prior to participation

You may not qualify if:

• The presence of other neurological or orthopaedic conditions that could affect gait or balance.
• Severe cognitive impairment (as determined by clinical history or physician report).
• Active MS relapses or corticosteroid treatment within the last 30 days.
• Visual or vestibular impairments that significantly interfere with gait or postural control.
• Diabetic patients will be excluded as this will interfere with balance.

Sponsors & Collaborators

• Ibrahim Ahmad Elmongy: lead
• Horus University: collaborator

Study Sites (1)

multiple sclerosis specialized clinic in the Neurology department, Faculty of Medicine, Alexandria University.

Alexandria, Egypt

Location

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Central Study Contacts

Ibrahim Ahmed Elmongy

CONTACT

+201061029866; ibrahem.abm1@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: teaching assistant

Study Record Dates

• First Submitted: March 30, 2026
• First Posted: April 13, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): July 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: April 13, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)