Contamination of Young Children Hair During Acute Cannabis Intoxication

NCT07524088 | Not Yet Recruiting

• 1 other identifier: RC31/24/0572
• Study Type: interventional
• Target: 15
• Locations: 0 countries
• Sites: N/A

Brief Summary

Hair analysis in pediatric cannabis intoxication is limited by possible sudoral self-contamination, especially in young children due to hair porosity. However, adult studies show no THC-COOH in sweat, challenging this hypothesis. THC-COOH presence in sweat has to this day never been studied in young children. Its absence would help assess the reliability of hair testing for prior exposure. Thus, our main objective is to describe whether THC-COOH can be detected in sweat following cannabis intoxication using gold standard techniques.

Conditions

Cannabis Intoxication in Children

Keywords

cannabis intoxication; children; sudroral contamination

Outcome Measures

Primary Outcomes (1)

• Acide 11-nor-9-carboxy-THC (THC-COOH) concentrations in sweat collected during the first 24 hours following emergency admission.

  concentration measured in sudoral sample (in µg/l)

  Day 1

Secondary Outcomes (2)

• Tétrahydrocannabinol (THC), 11-hydroxy-tétrahydrocannabinol (OH-THC) and THC-COOH measured in blood and sweat collected during the first 24 hours following emergency admission.

  Day 1

• THC, OH-THC and THC-COOH measured in two hair samples.

  day 1 and the day of follow-up visit at month 1 or month 2

Study Arms (1)

intoxicated children

EXPERIMENTAL

children with an intoxication of cannabis admitted to emergency

Other: sudoral and hairing sampling

Interventions

sudoral and hairing sampling OTHER

Sweat sampling using the "sweat test" method, performed after skin stimulation with pilocarpine and a low electrical stimulation. Hair sampling during the follow-up consultation. Sweat, and capillary assays of THC and its main metabolites

intoxicated children

Eligibility Criteria

• Age: 3 Months - 3 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Child admitted to the Specialized Emergency Pole (POSU) and pediatric medico-surgical emergencies for acute cannabis intoxication.
• Child older than 3 months and younger than 3 years.
• Holders of parental authority, affiliated with or beneficiaries of a social security system.

You may not qualify if:

• History of cannabis intoxication identified during the interview and/or consultation of the medical record.
• Contraindication to sweat sampling (described in section 6).
• Ongoing breastfeeding (exclusive and mixed).
• Inability to provide study-related informations to the holders of parental authority.

Sponsors & Collaborators

• University Hospital, Toulouse: lead
• University Hospital, Limoges: collaborator

Study Officials

• Thomas Lanot

  University Hospital of Toulouse

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nadège Algans

CONTACT

0561777204; algans.n@chu-toulouse.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 2, 2026
• First Posted: April 13, 2026
• Study Start: April 15, 2026
• Primary Completion (Estimated): February 20, 2028
• Study Completion (Estimated): April 15, 2028
• Last Updated: April 13, 2026

Record last verified: 2026-04