NCT07522983

Brief Summary

To compare the frequency of recurrent laryngeal injury during total thyroidectomy when utilizing the LigaSure technique against conventional knot tying.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
120

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jul 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 7, 2025

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 7, 2026

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 25, 2026

Completed
1 day until next milestone

First Submitted

Initial submission to the registry

March 26, 2026

Completed
18 days until next milestone

First Posted

Study publicly available on registry

April 13, 2026

Completed
Last Updated

April 13, 2026

Status Verified

April 1, 2026

Enrollment Period

6 months

First QC Date

March 26, 2026

Last Update Submit

April 4, 2026

Conditions

Thyroidectomy

Keywords

Thyroid glandMulti nodular goiter

Outcome Measures

Primary Outcomes (1)

  • Recurrent laryngeal nerve injury

    Patients will be admitted to the hospital ward and assessed for recurrent laryngeal injury as per the operational definition during their stay.

    3 days

Study Arms (2)

Group knot tying

EXPERIMENTAL

Group A will consist of patients designated for total thyroidectomy with tie and knot hemostasis

Procedure: tie and knot

Group ligasure

EXPERIMENTAL

Group B will comprise patients scheduled for total thyroidectomy using Ligasure for hemostasis

Procedure: Ligasure

Interventions

tie and knotPROCEDURE

patients designated for total thyroidectomy with tie and knot hemostasis

Also known as: Group conventional vessel sealing
Group knot tying
LigasurePROCEDURE

Ligasure for hemostasis

Also known as: Ligasure vessel sealing
Group ligasure

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Aged: 18 to 60 years
  • Both Gender
  • Patients undergoing total thyroidectomy
  • Normal IDL
  • No Hoarseness of voice

You may not qualify if:

  • Patients requiring re-operation, including completion thyroidectomy.
  • Patients undergoing concurrent procedures such as cervical lymphadenectomy or parathyroidectomy.
  • Patient having previous neck surgery
  • Patient having neck radiation
  • Thyroidectomy for thyroid malignancy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Gulab Devi Hospital Ferozpur Road Lahore

Lahore, Punjab Province, 54600, Pakistan

Location

MeSH Terms

Conditions

Thyroid Diseases

Condition Hierarchy (Ancestors)

Endocrine System Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
SCREENING
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Post graduate Resident

Study Record Dates

First Submitted

March 26, 2026

First Posted

April 13, 2026

Study Start

July 7, 2025

Primary Completion

January 7, 2026

Study Completion

March 25, 2026

Last Updated

April 13, 2026

Record last verified: 2026-04

Locations

PA(1)