M-TAPA vs OSTAP for Postoperative Analgesia in Laparoscopic Inguinal Hernia

NCT07522853 | Completed

• 1 other identifier: 2025-KAEK-43
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial aims to compare the postoperative analgesic efficacy of M-TAPA block and OSTAP block in patients undergoing laparoscopic inguinal hernia repair. Pain scores, analgesic consumption, and patient satisfaction will be evaluated.

Conditions

Inguinal Hernia Bilateral; Postoperative Pain

Keywords

MTAPA; OSTAP; Postoperative pain; TAP Block; VAS Score

Outcome Measures

Primary Outcomes (1)

• Total analgesic consumption in 24 hours

  Total amount of dexketoprofen consumed in the first 24 hours after surgery

  24 hours postoperative

Secondary Outcomes (5)

• Postoperative Pain Intensity (VAS Score)

  0 (15 minutes), 2, 4, 8, 12, 16, and 24 hours postoperative

• Time to First Analgesic Requirement

  Within 24 hours postoperative

• Tramadol Consumption

  24 hours postoperative

• Patient Satisfaction Score

  24 hours postoperative

• Incidence of Postoperative Nausea and Vomiting

  24 hours postoperative

Study Arms (3)

M-TAPA

EXPERIMENTAL

Bilateral M-TAPA block applied after surgery

Procedure: Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA)

OSTAP

EXPERIMENTAL

Bilateral OSTAP block applied after surgery

Procedure: Oblique Subcostal Transversus Abdominis Plane Block (OSTAP)

CONTROL

OTHER

No block applied and standart analgesia procedure

Other: Standard Analgesia use (paracetamol, contramal)

Interventions

Oblique Subcostal Transversus Abdominis Plane Block (OSTAP) PROCEDURE

Ultrasound-guided bilateral OSTAP block performed with 20 mL of 0.25% bupivacaine per side

OSTAP

Modified Thoracoabdominal Nerve Block Through Perichondrial Approach (M-TAPA) PROCEDURE

Ultrasound-guided bilateral M-TAPA block performed with 20 mL of 0.25% bupivacaine per side

M-TAPA

Standard Analgesia use (paracetamol, contramal) OTHER

Patients received standard postoperative analgesia without regional block

CONTROL

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged between 18 and 65 years
• American Society of Anesthesiologists (ASA) physical status I-II
• Scheduled for elective laparoscopic inguinal hernia repair (TEP technique)
• Ability to understand and use the Visual Analog Scale (VAS)
• Provided written informed consent

You may not qualify if:

• Refusal to participate or inability to provide informed consent
• Age under 18 or over 65 years
• ASA physical status ≥ III
• Coagulopathy (including abnormal INR, thrombocytopenia, or platelet dysfunction)
• Infection at the injection site
• Known allergy or hypersensitivity to study medications (local anesthetics, NSAIDs, opioids)
• Chronic opioid use (longer than 4 weeks)
• Use of psychiatric medications affecting pain perception
• Inability to cooperate or communicate effectively
• Requirement for postoperative intensive care

Sponsors & Collaborators

• Dr. Lutfi Kirdar Kartal Training and Research Hospital: lead

Study Sites (1)

Kartal Dr. Lütfi Kırdar City Hospital

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative

Interventions

Acetaminophen; Tramadol

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Acetanilides; Anilides; Amides; Organic Chemicals; Aniline Compounds; Amines; Cyclohexanols; Hexanols; Fatty Alcohols; Alcohols; Dimethylamines; Methylamines; Lipids

Study Officials

• Tahsin Simsek, MD

  Kartal Dr. Lütfi Kirdar City Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, Resident in Anesthesiology and Reanimation

Study Record Dates

• First Submitted: April 4, 2026
• First Posted: April 13, 2026
• Study Start: April 8, 2025
• Primary Completion: September 20, 2025
• Study Completion: September 20, 2025
• Last Updated: April 13, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)