Integrated Rehabilitation in HDU for Post-Intensive Care SyndromeLiberation in Patients With PICS

NCT07521540 | Not Yet Recruiting

• 1 other identifier: 2026bkky-hxk-PICS
• Study Type: interventional
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

Post-intensive care syndrome (PICS) is characterized by persistent physical, cognitive, and psychological impairments among survivors of critical illness. Although advances in intensive care medicine have reduced mortality, a large proportion of ICU survivors experience long-term functional impairments after discharge. High-dependency units (HDUs) serve as transitional care settings between intensive care units and general wards. Many critically ill survivors who cannot directly return home are transferred to HDU for continued treatment and rehabilitation. However, evidence regarding systematic multidisciplinary rehabilitation interventions in HDU settings remains limited. This prospective single-center interventional study aims to evaluate the effects of an integrated multidisciplinary rehabilitation model implemented in the HDU on physical, cognitive, and psychological outcomes among patients with post-intensive care syndrome. All enrolled patients will receive standardized integrated medical, nursing, and rehabilitation interventions. Multidimensional functional assessments will be conducted at baseline, during hospitalization, and before discharge from the HDU.

Conditions

Post-Intensive Care Syndrome (PICS); Mechanical Ventilation; Critical Illness Recovery

Keywords

Ventilator liberation; High-dependency unit; Post-ICU rehabilitation

Outcome Measures

Primary Outcomes (1)

• Change in Physical Function (CPAx Score)

  Change in Chelsea Critical Care Physical Assessment Tool (CPAx) score from baseline to HDU discharge. The CPAx score ranges from 0 to 50, with higher scores indicating better physical function.

  Baseline (within 48 hours after HDU admission) and at HDU discharge，assessed up to 2 days

Study Arms (1)

Integrated Multidisciplinary Rehabilitation in HDU

EXPERIMENTAL

Participants transferred from the intensive care unit (ICU) to the high-dependency unit (HDU) who meet the diagnostic criteria for post-intensive care syndrome (PICS) will receive an integrated multidisciplinary rehabilitation program during their HDU stay. The intervention includes coordinated medical management, respiratory rehabilitation, physical rehabilitation, rehabilitation nursing, and cognitive and psychological interventions delivered by a multidisciplinary team.

Behavioral: Integrated Multidisciplinary Rehabilitation

Interventions

Integrated Multidisciplinary Rehabilitation BEHAVIORAL

Participants will receive a standardized multidisciplinary rehabilitation program implemented in the HDU, including: Medical management Continuous treatment of primary diseases, medication optimization, complication prevention, and gradual removal of medical devices. Respiratory rehabilitation Respiratory muscle training, airway clearance techniques, and breathing pattern training. Physical rehabilitation Progressive mobilization according to patient tolerance, including passive exercises, active bed exercises, sitting training, standing training, and walking training. Sessions are conducted 1-2 times per day, lasting 20-40 minutes each. Rehabilitation nursing Position management, pressure injury prevention, device safety management, and sleep management. Cognitive and psychological interventions Orientation training, cognitive stimulation activities, psychological support, and family participation.

Integrated Multidisciplinary Rehabilitation in HDU

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥18 years
• Diagnosed with post-intensive care syndrome
• Transferred from ICU to HDU
• Available paired admission and discharge data

You may not qualify if:

• Death within 24 hours after HDU admission
• Missing primary outcome data

Sponsors & Collaborators

• Hongying Jiang, MD: lead

Study Sites (1)

Beijing Rehabilitation Hospital Affiliated to Capital Medical University

Beijing, Shijingshan, 100144, China

Location

MeSH Terms

Conditions

postintensive care syndrome

Study Officials

• Hongying Jiang, MD

  Beijing Rehabilitation Hospital of Capital Medical University

  STUDY CHAIR

Central Study Contacts

Jingyi Ge

CONTACT

+861056981098; ge_jingyi2020@163.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Sponsor-Investigator

Study Record Dates

• First Submitted: March 12, 2026
• First Posted: April 13, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): October 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: April 13, 2026

Record last verified: 2026-04

Locations

CN (1)