Predictive Value of Gastrointestinal Blood Flow for Enteral Nutrition Intolerance in Critically Ill Patients

NCT07521111 | Recruiting

• 1 other identifier: ZWQ-2026-GIBF
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to explore the correlation between gastrointestinal blood flow and the incidence of enteral nutrition intolerance (ENI) and its symptoms in critically ill patients, construct and compare predictive models including blood flow parameters, and evaluate their incremental predictive value.

Conditions

Critical Illness; Enteral Nutrition Intolerance; Enteral Nutrition Feeding; Prediction Models; Machine Learning

Outcome Measures

Primary Outcomes (1)

• Incidence of Enteral Nutrition Intolerance

  The rate of enteral nutrition intolerance occurs during the first 7 days of enteral nutrition support.

  Assessed daily from Day 1 to Day 7 of enteral nutrition

Secondary Outcomes (4)

• Incidence of gastrointestinal symptoms

  Assessed daily from Day 1 to Day 7 of enteral nutrition

• Achievement rate of targeted feeding volume

  Assessed daily from Day 1 to Day 7 of enteral nutrition

• Length of ICU stay

  Until ICU discharge, up to 28 days

• 28-day mortality rate

  up to day 28 post-ICU admission

Study Arms (1)

Critically ill patients

Eligible ICU patients from Ruijin Hospital are receiving enteral nutrition.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult critically ill patients admitted to the Intensive Care Units (ICUs) of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine. These patients require continuous enteral nutrition support with an expected duration of more than 7 days.

You may qualify if:

• Age \> 18 years old.
• Expected duration of enteral nutrition support \> 7 days.
• Patients or their legal representatives sign the informed consent form.

You may not qualify if:

• History of major gastrointestinal surgery such as subtotal gastrectomy and gastrointestinal anastomosis.
• Contraindications to abdominal point-of-care ultrasound (POCUS) examination (e.g., recent large-area abdominal burns, dressings blocking movement, open abdomen).
• Presence of severe gastrointestinal diseases such as gastroparesis, intestinal obstruction, digestive tract perforation, and gastrointestinal bleeding upon admission.
• Presence of severe peripheral vascular disease or valvular heart disease.
• Pregnant or lactating women.

Sponsors & Collaborators

• Ruijin Hospital: lead

Study Sites (1)

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, China

RECRUITING

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Weiqing Zhang, Ph.D

CONTACT

8618521525300; weiq.zh@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 28 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 2, 2026
• First Posted: April 9, 2026
• Study Start: January 25, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): June 30, 2027
• Last Updated: April 9, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)