Serum Myostatin and Irisin Levels in Postmenopausal Women: Association With Bone Mineral Density and Muscle Strength

NCT07519551 | Not Yet Recruiting

• 1 other identifier: MYO-IRISIN-BMD-2026-01
• Study Type: observational
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to evaluate the relationship between serum myostatin and irisin levels and bone mineral density and muscle strength in postmenopausal women. Participants will be grouped according to bone mineral density as normal, osteopenic, or osteoporotic. Serum myostatin and irisin levels will be measured, and muscle strength will be assessed using handgrip strength and the five times sit-to-stand test. The associations between biochemical and functional parameters will be analyzed.

Conditions

Osteoporosis, Osteopenia

Outcome Measures

Primary Outcomes (1)

• Relationship between serum myostatin and irisin levels and bone mineral density (T-score)

  Serum myostatin and irisin levels will be measured from fasting venous blood samples, and bone mineral density will be assessed using dual-energy X-ray absorptiometry (DEXA). The relationship between these parameters will be evaluated.

  Baseline

Secondary Outcomes (2)

• Relationship between serum myostatin and irisin levels and muscle strength

  Baseline

• Comparison of serum myostatin and irisin levels among bone mineral density groups

  Baseline

Study Arms (3)

Normal BMD

Postmenopausal women with normal bone mineral density based on dual-energy X-ray absorptiometry (DEXA) T-scores.

Osteopenia

Postmenopausal women with osteopenia defined by dual-energy X-ray absorptiometry (DEXA) T-scores.

Osteoporosis

Postmenopausal women with osteoporosis defined by dual-energy X-ray absorptiometry (DEXA) T-scores.

Eligibility Criteria

• Age: 50 Years - 65 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of postmenopausal women aged between 50 and 65 years who attend the outpatient clinic and meet the inclusion criteria. Participants will be classified into normal, osteopenic, and osteoporotic groups based on bone mineral density measurements obtained by dual-energy X-ray absorptiometry (DEXA).

You may qualify if:

• Postmenopausal women aged between 50 and 65 years Availability of bone mineral density measurement by dual-energy X-ray absorptiometry (DEXA) Willingness to participate in the study

You may not qualify if:

• Presence of malignancy Chronic kidney disease Chronic liver disease Neuromuscular disorders Recent major surgery or trauma Use of medications affecting bone or muscle metabolism

Sponsors & Collaborators

• Kanuni Sultan Suleyman Training and Research Hospital: lead
• Saglik Bilimleri Universitesi: collaborator

Biospecimen

Retention: SAMPLES WITHOUT DNA

Venous blood samples will be collected from participants after overnight fasting. Blood samples will be centrifuged to obtain serum, which will be used for the measurement of myostatin and irisin levels using appropriate laboratory methods. No genetic analysis will be performed, and samples will be used only for the purposes of this study.

MeSH Terms

Conditions

Osteoporosis; Bone Diseases, Metabolic

Condition Hierarchy (Ancestors)

Bone Diseases; Musculoskeletal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Zeynep Karakuzu Güngör, M.D

  Saglik Bilimleri Universitesi

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Zeynep Karakuzu Güngör, M.D

CONTACT

+905077750375; zeynepkarakuzu@hotmail.com.tr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist in Physical Medicine and Rehabilitation

Study Record Dates

• First Submitted: April 2, 2026
• First Posted: April 9, 2026
• Study Start: April 3, 2026
• Primary Completion: May 15, 2026
• Study Completion: May 30, 2026
• Last Updated: April 9, 2026

Record last verified: 2026-04