Medication Understanding in MS

NCT07518381 | Not Yet Recruiting

• 2 other identifiers: 26008368655
• Study Type: observational
• Target: 80
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this observational study is to learn how people with multiple sclerosis (MS) understand, organise, and use their medicines at home. The study aims to explore how people take their prescribed and non-prescribed medicines, what challenges they experience, and whether any safety issues arise in day-to-day medication use. Participants will take part in one home visit with trained student researchers. During the visit, researchers will review all medicines and supplements the participant uses, ask about routines and any difficulties, check medication packaging with permission, and ask a brief question about memory. No treatment changes will be made. Information will be reviewed by a senior clinician, and any safety concerns will be shared with the participant's usual healthcare team.

Conditions

Multiple Sclerosis

Keywords

polypharmacy; medication use; medication understanding; medication management; multiple sclerosis; adherence; medication burden; home medication review

Outcome Measures

Primary Outcomes (1)

• Medication Burden (Descriptive)

  Total number of prescribed and non-prescribed medications and supplements used by each participant, recorded during the home-based medication review. This includes dose, frequency, route, and source of each item. The outcome will be summarised descriptively (counts, means, ranges).

  Baseline

Secondary Outcomes (5)

• Medication Adherence (MARS-5 Score)

  Baseline

• Medication-Related Challenges

  Baseline

• Subjective Cognitive Decline (Single-Item Question)

  Baseline

• Medication Organisation and Use of Aids

  Baseline

• Medication Storage and Safety Issues

  Baseline

Study Arms (1)

People with multiple sclerosis

Adults with multiple sclerosis living in the community who will receive a single home-based medication review.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

From outpatient neurology (Nottingham) and rehabilitation medicine (Derby) settings

You may qualify if:

• Adults aged 18 years and over with a confirmed diagnosis of multiple sclerosis
• Living in the community (not in residential care)
• Taking at least one prescribed medication
• Able to provide informed consent or, for those without capacity to provide informed consent, with a consultee available to provide consultee declaration and provide information during home-based medication review
• Willing and able to participate in a home-based medication review

You may not qualify if:

• Severe cognitive or communication impairment without a consultee to provide consultee declaration and medication-related information
• Participants for whom a home visit is deemed unsafe
• Non-English speakers

Sponsors & Collaborators

• Nottingham University Hospitals NHS Trust: collaborator
• University of Nottingham: lead
• University Hospitals of Derby and Burton NHS Foundation Trust: collaborator

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Central Study Contacts

Laura Edwards, FRCP PhD

CONTACT

01332258238; laura.edwards@nottingham.ac.uk

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 25, 2026
• First Posted: April 8, 2026
• Study Start: April 15, 2026
• Primary Completion: July 15, 2026
• Study Completion: September 1, 2026
• Last Updated: April 8, 2026

Record last verified: 2026-03