Effect of Collagen Peptides on Skin Health: A Clinical Trial

NCT07516756 | Completed

• 1 other identifier: SECCR2024-97-01
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to evaluate whether daily oral supplementation with 2.5 g of specific bioactive collagen peptides (SCP) can improve skin physiology in healthy adult women aged 35-55 years. The main questions it aims to answer are: Does SCP supplementation increase skin hydration and barrier function? Does SCP improve skin elasticity, firmness, and collagen content? Does SCP reduce the appearance of periorbital wrinkles and improve overall skin appearance? Researchers will compare SCP supplementation to a placebo (a look-alike substance containing no collagen peptides) to see if SCP supports skin structure and appearance over eight weeks. Participants will: Consume one sachet of SCP or placebo daily for eight weeks Attend three study visits at baseline, week 4, and week 8 for facial imaging, instrumental skin measurements, and expert assessments Have objective measures taken, including skin hydration, transepidermal water loss, elasticity, firmness, dermal collagen content, and 3D wrinkle morphology Complete subjective skin assessments rated by trained evaluators using a visual analogue scale Report any adverse events or intolerance reactions at each visit This study is designed to provide an integrated evaluation of multiple skin parameters, including barrier function, biomechanical properties, dermal matrix composition, and wrinkle characteristics, in a single trial. By combining objective and subjective measures, the study aims to generate robust and clinically interpretable evidence for the effects of oral collagen peptide supplementation on skin health.

Conditions

Age-related Changes in Skin Appearance and Physiology

Keywords

Bioactive collagen peptides; Oral supplementation; Skin aging; Skin hydration; Skin elasticity; Skin firmness; Wrinkles / periorbital wrinkles; Dermal extracellular matrix; Skin barrier function; Skin physiology; Healthy adult women; Randomized controlled trial (

Outcome Measures

Primary Outcomes (1)

• stratum corneum hydration (SCH)

  Stratum corneum hydration (SCH) measures the water content in the outermost layer of the skin, reflecting the skin's ability to retain moisture and maintain a healthy barrier. In this study, SCH is the primary efficacy endpoint, used to compare the effect of daily oral supplementation with specific bioactive collagen peptides (SCP) versus placebo over an 8-week period. SCH is assessed using a Corneometer CM825 at the cheek. Each site is measured six times, and the mean value is used for analysis. Higher SCH values indicate better skin hydration, whereas lower values suggest dryness or impaired barrier function. Changes in SCH over time are compared between the treatment and placebo groups to evaluate the impact of collagen peptide supplementation on skin hydration.

  From enrollment to the end of treatment at 8 weeks

Secondary Outcomes (5)

• Transepidermal Water Loss (TEWL)

  From enrollment to the end of treatment at 8 weeks

• Skin Elasticity (R2 and R5) and Firmness (F4)

  From enrollment to the end of treatment at 8 weeks

• Dermal collagen content

  From enrollment to the end of treatment at 8 weeks

• Wrinkle Morphology

  From enrollment to the end of treatment at 8 weeks

• Skin Appearance (3D Imaging + VAS)

  From enrollment to the end of treatment at 8 weeks

Study Arms (2)

Specific Collagen Peptides

EXPERIMENTAL

Participants in this arm receive 2.5 g of specific bioactive collagen peptides (VERISOL®) once daily for 8 weeks. The powder is dissolved in warm water and consumed orally. The supplement contains defined collagen peptides derived from bovine type I collagen, which have been shown to support skin hydration, elasticity, firmness, dermal collagen content, and wrinkle reduction. Participants continue their usual lifestyle habits while taking the supplement.

Dietary Supplement: Specific Collagen Peptides

Maltodextrin

PLACEBO COMPARATOR

Participants in this arm receive a matching placebo sachet once daily for 8 weeks. The placebo contains plant-derived maltodextrin and is identical in appearance, taste, and texture to the collagen peptide supplement. It is dissolved in warm water and consumed orally. Participants continue their usual lifestyle habits while taking the placebo.

Dietary Supplement: Placebo

Interventions

Placebo DIETARY_SUPPLEMENT

Participants in this arm receive a matching placebo sachet once daily for 8 weeks. The placebo contains plant-derived maltodextrin and is identical in appearance, taste, and texture to the collagen peptide supplement. It is dissolved in warm water and consumed orally. Participants continue their usual lifestyle habits while taking the placebo.

Maltodextrin

Specific Collagen Peptides DIETARY_SUPPLEMENT

Participants in this arm receive 2.5 g of specific bioactive collagen peptides (VERISOL®) once daily for 8 weeks. The powder is dissolved in warm water and consumed orally. The supplement contains defined collagen peptides derived from bovine type I collagen, which have been shown to support skin hydration, elasticity, firmness, dermal collagen content, and wrinkle reduction. Participants continue their usual lifestyle habits while taking the supplement.

Specific Collagen Peptides

Eligibility Criteria

• Age: 35 Years - 55 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Fitzpatrick skin type III-IV
• Presence of crow's feet wrinkles graded 2-4
• Presence of under-eye fine lines graded 2-5
• Generally in good health
• Able to comply with study procedures and visit schedule

You may not qualify if:

• Use of systemic or topical anti-inflammatory medication, including corticosteroids, within the 4 weeks prior to baseline
• Known hypersensitivity or allergy to any ingredient of the investigational products
• Pregnancy, breastfeeding, or intention to become pregnant during the study period
• History of relevant dermatological conditions: psoriasis, eczema, atopic dermatitis, or severe acne
• Presence of birthmarks, hyperpigmentation, active inflammation, or other visible skin abnormalities in the test areas
• Recent aesthetic procedures Use of anti-aging or topical treatments
• Intake of nutritional supplements
• Participation in other clinical studies within the past 2 months
• Significant lifestyle or dietary changes during the study period
• Excessive UV exposure
• Systemic diseases, including heart, immune, vascular, liver, gallbladder, or kidney disorders
• Known allergies to foods, cosmetics, skincare products, or topical medications
• Any other condition that, in the investigator's opinion, would make the participant ineligible

Sponsors & Collaborators

• Collagen Research Institute: lead
• GELITA: collaborator

Study Sites (1)

Beijing EWISH Testing Technology Co., Ltd

Beijing, Haidan, 100142, China

Location

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Study Officials

• Steffen Oesser, Dr

  Collagen Research Institute, Schauenburgerstr. 116, D-24118 Kiel

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 1, 2026
• First Posted: April 8, 2026
• Study Start: August 8, 2024
• Primary Completion: October 4, 2024
• Study Completion: October 4, 2024
• Last Updated: April 8, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)