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The Neural Mechanisms of Emotion Dysregulation in Repetitive Negative Thinking (RNT) Patients: A Pilot Study
Sponsor study identifier
observational
100
1 country
1
Study Start
June 5, 2024
Actual (reported)Primary Completion
March 30, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 30, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The goal of this study is to understand why some people become stuck in repetitive negative thinking, which is common among individuals with depression and anxiety. Repetitive negative thinking involves repeatedly focusing on negative events, worries, or problems. These thoughts can be difficult to control and may worsen emotional distress and daily functioning. Researchers believe that repetitive negative thinking may be related to changes in how different brain networks communicate with each other. This study will examine how the brain responds during emotion regulation tasks in people who tend to ruminate compared with healthy individuals. To do this, researchers will use a brain-imaging technique called functional near-infrared spectroscopy (fNIRS). This method measures brain activity using harmless infrared light while participants perform tasks on a computer. The main questions this study aims to answer are: How does the brain respond to emotional situations in people who experience repetitive negative thinking? Are there differences in brain activity between people with depression or anxiety and healthy individuals during emotion regulation? Participants will include 50 healthy volunteers and 50 individuals with depression or anxiety who experience repetitive negative thinking. Participants will: Wear a lightweight brain-imaging device (fNIRS) placed on the head to measure brain activity Complete computer tasks involving emotional images and different emotion-regulation strategies, such as reinterpreting, suppressing, or distracting from emotions Listen to different types of spoken feedback (criticism, praise, or neutral comments) and imagine receiving them from someone they know Report their emotional feelings during the tasks Complete several questionnaires about mood, thinking patterns, and emotional experiences During the experiment, researchers will also record physiological responses such as heart activity and skin reactions, which are related to emotional responses. The results of this study may help researchers better understand the brain mechanisms underlying rumination and may contribute to the development of more effective treatments for depression and anxiety.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 30, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 5, 2024
Actual (reported)March 19, 2026
Actual (reported)March 30, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
April 7, 2026
Actual (reported)December 30, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Perseverative Thinking Questionnaire (PTQ) total score
The Perseverative Thinking Questionnaire (PTQ) total score will be used to assess repetitive negative thinking at baseline. Baseline PTQ total scores will be compared between patients and healthy controls.
During a single laboratory session (baseline assessment)
Penn State Worry Questionnaire (PSWQ) score
The Penn State Worry Questionnaire (PSWQ) total score will be used to assess worry at baseline. Baseline PSWQ total scores will be compared between patients and healthy controls
During a single laboratory session (baseline assessment)
Leuven Adaptation of the Rumination on Sadness Scale (LARSS) score
The Leuven Adaptation of the Rumination on Sadness Scale (LARSS) score will be used to assess rumination at baseline. Baseline LARSS total scores will be compared between patients and healthy controls.
During a single laboratory session (baseline assessment)
Mean task-evoked oxygenated hemoglobin (HbO) changes in cortical regions-mainly the dorsolateral prefrontal cortex and precuneus-during the emotion regulation task, as measured by fNIRS.
During a single laboratory session (baseline assessment)
Mean task-evoked oxygenated hemoglobin (HbO) change in prefrontal cortical regions during the critical paradigm measured by fNIRS
During a single laboratory session (baseline assessment)
Mean resting-state functional connectivity in prefrontal cortical regions measured by fNIRS
During a single laboratory session (baseline assessment)
Mean heart rate during experimental tasks measured by electrocardiography (ECG)
During a single laboratory session (baseline assessment)
Mean skin conductance response amplitude during experimental tasks measured by skin conductance recording (SCR)
During a single laboratory session (baseline assessment)
People who have a current or past history of anxiety and/or depression
People who do not have a current or past history of anxiety and/or depression
Patient group mainly consists of individuals diagnosed with depression or generalized anxiety disorder (GAD).
University Hospital Ghent, Ghent, East-Flanders 9000
Ghent, 9000, Belgium
Morawetz C, Riedel MC, Salo T, Berboth S, Eickhoff SB, Laird AR, Kohn N. Multiple large-scale neural networks underlying emotion regulation. Neurosci Biobehav Rev. 2020 Sep;116:382-395. doi: 10.1016/j.neubiorev.2020.07.001. Epub 2020 Jul 11.
Fitzgerald JM, Klumpp H, Langenecker S, Phan KL. Transdiagnostic neural correlates of volitional emotion regulation in anxiety and depression. Depress Anxiety. 2019 May;36(5):453-464. doi: 10.1002/da.22859. Epub 2018 Nov 8.
Chris Baeken
University Ghent
First Submitted
March 19, 2026
First Posted
April 7, 2026
Study Start
June 5, 2024
Actual (reported)Primary Completion
March 30, 2026
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Ruminative Responses Scale (RRS) score
The Ruminative Responses Scale (RRS) score will be used to assess rumination at baseline. Baseline RRS total scores will be compared between patients and healthy controls.
During a single laboratory session (baseline assessment)
Contact the study team to confirm eligibility.
Demichelis OP, Grainger SA, Hubbard RE, Henry JD. Emotion regulation mediates the relationship between social frailty and stress, anxiety, and depression. Sci Rep. 2023 Apr 20;13(1):6430. doi: 10.1038/s41598-023-33749-0.
Watkins ER, Roberts H. Reflecting on rumination: Consequences, causes, mechanisms and treatment of rumination. Behav Res Ther. 2020 Apr;127:103573. doi: 10.1016/j.brat.2020.103573. Epub 2020 Jan 31.
Spinhoven P, van Hemert AM, Penninx BW. Repetitive negative thinking as a predictor of depression and anxiety: A longitudinal cohort study. J Affect Disord. 2018 Dec 1;241:216-225. doi: 10.1016/j.jad.2018.08.037. Epub 2018 Aug 10.
Study Completion
December 30, 2026
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
April 7, 2026
Record last verified: 2026-03
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