NCT07509580

Brief Summary

Lumbar radiculopathy caused by conditions such as lumbar disc herniation (LDH) and lumbar spinal stenosis (LSS) can lead to chronic pain and reduced quality of life. In patients who do not respond to conservative treatments, minimally invasive procedures such as transforaminal epidural steroid injection (TFESI) and pulsed radiofrequency (pRF) applied to the dorsal root ganglion (DRG) are commonly used. This study aims to compare treatment responses between patients with lumbar disc herniation and those with lumbar spinal stenosis who have undergone TFESI combined with dorsal root ganglion pulsed radiofrequency. Pain levels and clinical outcomes will be evaluated to determine whether the underlying condition affects treatment effectiveness. The results of this study may help guide clinicians in selecting the most appropriate treatment approach for patients with lumbar radiculopathy.

Trial Health

75
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
1mo left

Started Nov 2024

Geographic Reach
1 country

1 active site

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress96%
Nov 2024Jun 2026

Study Start

First participant enrolled

November 1, 2024

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2025

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

March 29, 2026

Completed
5 days until next milestone

First Posted

Study publicly available on registry

April 3, 2026

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2026

Expected
Last Updated

April 22, 2026

Status Verified

March 1, 2026

Enrollment Period

1.1 years

First QC Date

March 29, 2026

Last Update Submit

April 18, 2026

Conditions

Lumbar RadiculopathyLumbar Disc HerniationLumbar Spinal Stenosis (LSS)

Keywords

Lumbar radiculopathyTransforaminal epidural steroid injectionTFESIDorsal root ganglionPulsed radiofrequencyDRG pulsed RFLumbar disc herniationLumbar spinal stenosisInterventional pain managementNeuromodulation

Outcome Measures

Primary Outcomes (1)

  • Comparison of change in pain intensity (Numeric Rating Scale, NRS) between lumbar disc herniation and lumbar spinal stenosis

    Pain intensity will be assessed using the Numeric Rating Scale (0-10), and changes from baseline at 1 hour and 3 weeks post-procedure will be compared between patients with lumbar disc herniation and lumbar spinal stenosis.

    Baseline, 1 hour, and 3 weeks post-procedure

Secondary Outcomes (1)

  • Radiological severity grading

    Baseline (based on pre-procedural MRI)

Study Arms (2)

Lumbar Disc Herniation

Patients diagnosed with lumbar disc herniation (LDH) who underwent transforaminal epidural steroid injection (TFESI) and dorsal root ganglion (DRG) pulsed radiofrequency (pRF).

Lumbar Spinal Stenosis

Patients diagnosed with lumbar spinal stenosis (LSS) who underwent transforaminal epidural steroid injection (TFESI) and dorsal root ganglion (DRG) pulsed radiofrequency (pRF).

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The study population consists of adult patients aged 18-75 years with lumbar radiculopathy secondary to lumbar disc herniation or lumbar spinal stenosis, who underwent transforaminal epidural corticosteroid injection and dorsal root ganglion pulsed radiofrequency at the Algology Clinic of Marmara University Pendik Training and Research Hospital between November 2024 and November 2025. Patients with a symptom duration of at least 3 months and with available clinical and radiological records are included in the analysis.

You may qualify if:

  • Age between 18 and 75 years
  • Presence of symptoms associated with lumbar spinal stenosis or lumbar disc herniation
  • Symptom duration of at least 3 months
  • Having undergone lumbar transforaminal epidural corticosteroid injection and dorsal root ganglion pulsed radiofrequency

You may not qualify if:

  • Absence of sufficient records in the hospital system
  • Inaccessibility of radiological imaging

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Marmara University Faculty of Medicine

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

RadiculopathyIntervertebral Disc DisplacementSpinal Stenosis

Condition Hierarchy (Ancestors)

Peripheral Nervous System DiseasesNeuromuscular DiseasesNervous System DiseasesSpinal DiseasesBone DiseasesMusculoskeletal DiseasesHerniaPathological Conditions, AnatomicalPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor, MD

Study Record Dates

First Submitted

March 29, 2026

First Posted

April 3, 2026

Study Start

November 1, 2024

Primary Completion

November 30, 2025

Study Completion (Estimated)

June 1, 2026

Last Updated

April 22, 2026

Record last verified: 2026-03

Locations

TU(1)