CALLY Index and Disease Activity in Ankylosing Spondylitis

NCT07509463 | Completed

• 1 other identifier: 2026-Rheumatology-6
• Study Type: observational
• Target: 65
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective cross-sectional observational study aims to evaluate the association between the C-reactive protein-albumin-lymphocyte (CALLY) index and disease activity and functional status in patients with ankylosing spondylitis. Medical records of adult patients followed between January 1, 2022, and December 31, 2025, were reviewed. Disease activity was assessed using BASDAI and ASDAS-ESR, and functional status was evaluated using BASFI. The study investigates whether the CALLY index reflects systemic inflammatory burden beyond patient-reported disease activity

Conditions

Anklyosing Spondylitis

Keywords

CALLY index; systemic inflammation; disease activity; BASDAI; ankylosing spondylitis

Outcome Measures

Primary Outcomes (1)

• BASDAI and ASDAS-ESR scores in relation to CALLY index

  Assessment of the relationship between the C-reactive protein-albumin-lymphocyte (CALLY) index and disease activity measures, including BASDAI and ASDAS-ESR, in patients with ankylosing spondylitis.

  At a single assessment time point

Secondary Outcomes (2)

• Correlation of CALLY index with BASFI score in patients with ankylosing spondylitis

  At a single assessment time point

• Correlation of CALLY index with CRP, ESR, lymphocyte count, and albumin levels in patients with ankylosing spondylitis

  At a single assessment time point

Study Arms (1)

Patients with ankylosing spondylitis

Patients aged 18 years and older with ankylosing spondylitis diagnosed according to the modified New York criteria, whose medical records were retrospectively reviewed between January 1, 2022, and December 31, 2025.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with ankylosing spondylitis who were followed at Bursa City Hospital, Türkiye, and whose medical records were retrospectively reviewed between January 1, 2022, and December 31, 2025.

You may qualify if:

• Age 18 years and older
• Diagnosis of ankylosing spondylitis according to the modified New York criteria
• Availability of complete clinical and laboratory data at a single assessment time point

You may not qualify if:

• Active or chronic infection
• Malignancy
• Advanced hepatic or renal disease
• Having conditions affecting serum albumin levels, such as nephrotic syndrome
• Incomplete data

Sponsors & Collaborators

• Bursa City Hospital: lead

Study Sites (1)

Bursa City Hospital

Bursa, Türkiye, 16600, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Spondylitis, Ankylosing

Condition Hierarchy (Ancestors)

Axial Spondyloarthritis; Spondylarthropathies; Spondylarthritis; Spondylitis; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Ankylosis; Joint Diseases; Arthritis

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 29, 2026
• First Posted: April 3, 2026
• Study Start: January 1, 2022
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: April 8, 2026

Record last verified: 2026-04

Locations

TU (1)