Emotions From Salivary Biomarkers in an Architectural Context

NCT07507266 | Not Yet Recruiting

• 2 other identifiers: 2025-A00909-4025.01443.000493#1
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Architecture influences our well-being. People's behavior and mood changes in different spaces are directly related to the architectural qualities of the built environment. Neuroarchitecture is a discipline that combines neuroscience and architecture to design spaces adapted to the psychological and physiological needs of users. Several studies related to neuroarchitecture have been conducted according to different architectural parameters such as style, natural environment, lighting, color, and sunlight pattern. Recent studies show that emotional states can be evaluated by physiological responses. This physiological regulation comes from the action of enzymes and hormones that represent the activity of the autonomic nervous system. Measuring specific biomarkers through non-invasive biological tests in saliva provides physiological data on an individual's emotional state in response to stimuli, particularly visual or tactile.

Conditions

Emotions

Keywords

Biomarkers; Architecture; Stimuli

Outcome Measures

Primary Outcomes (1)

• Evaluate the variation of salivary biomarkers, which may be linked to emotions (positive or negative), before and after interaction with an architectural work.

  Evaluate the variation of salivary biomarkers, which may be linked to emotions (positive or negative), before and after interaction with an architectural work. This exposure includes a combination of visual, tactile, and/or olfactory stimuli.

  2 years

Secondary Outcomes (4)

• Identify a salivary molecular biomarker signature linked to an emotional profile following exposure to an architectural site.

  2 years

• Compare the identified molecular biomarker signatures between the studied architectural sites (different types of visual, tactile, or olfactory stimuli).

  2 years

• Establish correlations between the identified biomarker signatures linked to emotional profiles and sociodemographic and developmental data.

  2 years

• Evaluate the homogeneity of the emotional physiological response following exposure to an architectural site.

  2 years

Study Arms (2)

ARM VT

30 subjects who will be exposed to an architectural work offering visual and tactile stimulations.

Diagnostic Test: Bio-fluid analysis for the measurement of salivary biomarkers linked to emotions

ARM O

30 subjects who will be exposed to a second architectural work offering visual, tactile, and olfactory stimulations.

Diagnostic Test: Bio-fluid analysis for the measurement of salivary biomarkers linked to emotions

Interventions

Bio-fluid analysis for the measurement of salivary biomarkers linked to emotions DIAGNOSTIC_TEST

Saliva of participants will be sampled for analysis of biomarkers of interest (DHEA, oxytocin, cortisol, alpha-amylase, serotonin, and dopamine) using enzymatic dosage methods or ELISA-type methods carried out using commercial kits.

ARM O; ARM VT

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy adult volunteers attending the architectural festival who got exposed and/or got an interaction with an architectural work, with visual, tactile, and/or olfactory stimuli.

You may qualify if:

• Subject over 18 years old
• Subject agreeing to follow the study procedures
• Subject capable of understanding the purpose, nature, and methodology of the study
• Subject affiliated with a French social security scheme or beneficiary of such a scheme.

You may not qualify if:

• Subject not affiliated with a French Social Security scheme or not a beneficiary of such a scheme
• Subject deprived of liberty, protected adult, vulnerable person, or minor
• Subject with proven or suspected chronic infectious disease that could pose a risk of contamination during sample handling (laboratories not equipped to handle this type of sample)
• Subject with a deficiency (vision, anosmia) preventing proper interaction with the architectural work
• Subject presenting signs of active oral inflammation, advanced periodontitis, or severe gingivitis
• Subject suffering from Gougerot-Sjögren syndrome (dry syndrome) or mouth cancer
• Pregnant or breastfeeding women.

Sponsors & Collaborators

• Sys2Diag: lead
• Centre National de la Recherche Scientifique, France: collaborator

Study Sites (1)

Sys2Diag - Umr9005 Cnrs/Alcen

Montpellier, 34184, France

Location

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Biospecimen

Retention: SAMPLES WITH DNA

Saliva

Study Officials

• Laurence MOLINA, PhD

  Sys2Diag

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Wendpouiré A OUEDRAOGO, Msc

CONTACT

+33 (0) 467 047 481; alimata.ouedraogo@sys2diag.cnrs.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Researcher/Project Manager

Study Record Dates

• First Submitted: March 26, 2026
• First Posted: April 2, 2026
• Study Start: June 9, 2026
• Primary Completion: June 14, 2026
• Study Completion (Estimated): June 14, 2028
• Last Updated: April 14, 2026

Record last verified: 2026-04

Locations

FR (1)