Effect of Pentoxyfilline on Endometrial Thickness and Frozen Embryo Transfer Outcomes

NCT07499817 | Recruiting Phase 3 DMC

• 1 other identifier: Trental /IVF
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this work was to investigate the effect of different vasodilators as pentoxifylline in women with unexplained infertility using IVF

Conditions

Embryo Transfer; IVF; Infertility

Keywords

thawed embryo; IVF

Outcome Measures

Primary Outcomes (1)

• Pregnancy

  Beta-Human Chorionic Gonadotropin (β-hCG) was positive

  1 month

Study Arms (2)

(control)

ACTIVE COMPARATOR

received estradiol valerate 2 mg. in form of (Cycloprogynova® Bayer Shering Pharma) white pills starting dose is one pill T.I.D may be increased to two pills T.I.D according to endometrial5 thickness in day 9 measured by vaginal ultrasound

Other: (control)

pentoxifylline 400 mg

EXPERIMENTAL

Once daily in form of (Trental ® Sanofi co.) daily in addition to the above treatment protocol from the first day of the cycle until the day of starting progesterone.

Drug: pentoxifylline 400 mg

Interventions

pentoxifylline 400 mg DRUG

Once daily in form of (Trental ® Sanofi co.) daily in addition to the above treatment protocol from the first day of the cycle until the day of starting progesterone.

Also known as: Trental ® Sanofi co.

pentoxifylline 400 mg

(control) OTHER

estradiol valerate 2 mg. in form of (Cycloprogynova® Bayer Shering Pharma) whitepills starting dose is one pill T.I.D

(control)

Eligibility Criteria

• Age: 18 Years - 43 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• as good quality day five frozen embryos.

You may not qualify if:

• history of endocrine diseases,
• history of any previous surgery that couldm compromise the integrity of endometrium,
• cardiovascular, renal and liver diseases,

Sponsors & Collaborators

• Beni-Suef University: lead

Study Sites (1)

Beni-suef university Hospital

Banī Suwayf, Beni Suweif Governorate, 62521, Egypt

RECRUITING

MeSH Terms

Conditions

Infertility

Interventions

Pentoxifylline

Condition Hierarchy (Ancestors)

Genital Diseases; Urogenital Diseases

Intervention Hierarchy (Ancestors)

Theobromine; Xanthines; Purinones; Purines; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Heterocyclic Compounds

Study Officials

• Beni suef University

  Beni-Suef University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sara A Salem, MD

CONTACT

01272842226; sara.abdalla@med.bsu.edu.eg

Study Design

• Study Type: interventional
• Phase: phase 3
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of obstetrics and gynecology

Study Record Dates

• First Submitted: March 19, 2026
• First Posted: March 30, 2026
• Study Start: October 1, 2023
• Primary Completion: April 1, 2026
• Study Completion: April 30, 2026
• Last Updated: March 30, 2026

Record last verified: 2026-03

Locations

EG (1)