Investigation of the Role of Internal Jugular Vein Collapsibility Index in Predicting Spinal Anesthesia-Induced Hypotension in Preeclamptic Parturients

NCT07496788 | Not Yet Recruiting

• 1 other identifier: TABED 1-25-1325
• Study Type: observational
• Target: 96
• Locations: 1 country
• Sites: 1

Brief Summary

This prospective, single-center observational study aims to evaluate the predictive value of the internal jugular vein collapsibility index (IJVCI) for spinal anesthesia-associated hypotension in preeclamptic parturients (gestational age ≥28 weeks) undergoing cesarean delivery classified as Lucas category 3-4. Preoperative IJVCI will be measured using ultrasonography before spinal anesthesia during spontaneous and deep respiration. The incidence of hypotension within the first 20 minutes after spinal anesthesia will be recorded. The diagnostic performance of IJVCI in predicting hypotension will be analyzed.

Conditions

Spinal Anesthesia-Induced Hypotension; Preeclampsia; Cesarean Section

Keywords

Preeclampsia; Spinal Anesthesia; Hypotension; Internal Jugular Vein; Collapsibility Index; Cesarean Section; Ultrasonography; Hemodynamic Monitoring

Outcome Measures

Primary Outcomes (1)

• Predictive Value of Internal Jugular Vein Collapsibility Index for Spinal Anesthesia-Induced Hypotension

  Diagnostic performance of the preoperative internal jugular vein collapsibility index (IJVCI) for predicting spinal anesthesia-associated hypotension within the first 20 minutes after spinal anesthesia, assessed by receiver operating characteristic (ROC) curve analysis. Hypotension will be defined as a ≥30% decrease in mean arterial pressure from baseline or systolic blood pressure \<100 mmHg.

  From spinal anesthesia administration to 20 minutes post-spinal anesthesia

Study Arms (1)

Preeclamptic Parturients Undergoing Cesarean Section

Preeclamptic pregnant women aged 18-45 years with ASA physical status II-III and gestational age ≥28 weeks who are scheduled for cesarean delivery under spinal anesthesia, with cesarean urgency classified as Lucas category 3-4. Preoperative internal jugular vein collapsibility index (IJVCI) will be measured using ultrasonography before spinal anesthesia, and participants will be followed for the development of spinal anesthesia-associated hypotension within the first 20 minutes after spinal anesthesia.

Other: Internal Jugular Vein Collapsibility Index Measurement

Interventions

Internal Jugular Vein Collapsibility Index Measurement OTHER

Preoperative ultrasonographic measurement of the internal jugular vein collapsibility index (IJVCI) performed before spinal anesthesia in preeclamptic parturients (gestational age ≥28 weeks) undergoing cesarean delivery classified as Lucas category 3-4.

Preeclamptic Parturients Undergoing Cesarean Section

Eligibility Criteria

• Age: 18 Years - 45 Years
• Gender Eligibility Details: This study includes only female participants because it investigates preeclamptic pregnant women undergoing cesarean delivery under spinal anesthesia, with cesarean urgency classified as Lucas category 3-4. Preeclampsia is a pregnancy-specific condition and therefore occurs only in pregnant women.
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Pregnant women diagnosed with preeclampsia who are scheduled for cesarean delivery under spinal anesthesia at Ankara Bilkent City Hospital, with cesarean urgency classified as Lucas category 3-4. Eligible participants are aged 18-45 years, have ASA physical status II-III, and have a gestational age ≥28 weeks. Participants will be evaluated for the development of spinal anesthesia-associated hypotension within the first 20 minutes after spinal anesthesia..

You may qualify if:

• Age between 18 and 45 years
• ASA physical status II-III
• Diagnosed with preeclampsia
• Scheduled for cesarean delivery under spinal anesthesia with cesarean urgency classified as Lucas category 3-4
• Gestational age ≥28 weeks
• Provided written informed consent

You may not qualify if:

• Cesarean urgency classified as Lucas category 1-2
• Gestational age \<28 weeks
• ASA physical status ≥ IV
• Known renal disease
• Cardiac instability or known arrhythmia
• Requirement of general anesthesia or sedation
• Inability to provide informed consent

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent City Hospital

Ankara, Ankara, 06800, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pre-Eclampsia; Hypotension

Condition Hierarchy (Ancestors)

Hypertension, Pregnancy-Induced; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Nihan Aydin Guzey, MD, PhD

  Ankara City Hospital Bilkent

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nihan Aydin Guzey, MD, PhD

CONTACT

+905056496231; nihanaydinguzey@gmail.com

Basak Mizrak Demirbuken, MD

CONTACT

+90509464248; basakmizrak@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor Nihan Aydin Guzey

Study Record Dates

• First Submitted: March 23, 2026
• First Posted: March 27, 2026
• Study Start: May 1, 2026
• Primary Completion (Estimated): July 25, 2026
• Study Completion (Estimated): July 25, 2026
• Last Updated: March 27, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)