Spontaneous Breathing Mode: A Risk for Hypoxemia During OLV?

NCT07494006 | Enrolling By Invitation

• 1 other identifier: 2025z-179
• Study Type: observational
• Target: 44
• Locations: 1 country
• Sites: 1

Brief Summary

Patients undergoing thoracic surgery with one-lung ventilation (OLV) are prone to hypoxemia, which is primarily attributable to pulmonary ventilation-perfusion (V/Q) mismatch. This study will preoperatively assess the distribution of pulmonary ventilation under spontaneous breathing and intraoperatively record the lowest peripheral oxygen saturation (SpO₂) during OLV. The aim is to investigate the correlation between these two parameters. The findings are expected to facilitate the prediction of hypoxemia in thoracic surgical patients undergoing OLV.

Conditions

Lung Cancer; OLV; Hypoxemia During Surgery

Keywords

EIT; OLV; Hypoxemia; lung cancer

Outcome Measures

Primary Outcomes (1)

• Lowest SpO₂ during OLV

  We will record the value of the lowest peripheral oxygen saturation (SpO₂) during intraoperative one-lung ventilation.

  Perioperative

Secondary Outcomes (2)

• Postoperative functional status

  Follow-up assessments with both questionnaires were conducted at 6 and 12 months postoperatively.

• postoperative quality of life

  Follow-up assessments with both questionnaires were conducted at 6 and 12 months postoperatively.

Study Arms (2)

Ventilation-Matched Group

In this patient group, the dependent lung exhibited better ventilation in the lateral decubitus position during spontaneous breathing than in the supine position.

Ventilation-Mismatched Group

In this patient group, ventilation of the dependent lung during spontaneous breathing in the lateral decubitus position was less effective than that in the supine position.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who underwent thoracoscopic partial pulmonary resection at Peking University People's Hospital

You may qualify if:

• Age ≥ 18 years
• BMI \> 18.5 and \< 30
• Informed consent obtained

You may not qualify if:

• Inability to use the EIT belt preoperatively
• Failure to implement one-lung ventilation during surgery

Sponsors & Collaborators

• Peking University People's Hospital: lead

Study Sites (1)

Peking University People's Hospital

Beijing, 100044, China

Location

Related Publications (13)

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• Spinelli E, Perez J, Chiavieri V, Leali M, Mansour N, Madotto F, Rosso L, Panigada M, Grasselli G, Vaira V, Mauri T. Pathophysiological Markers of Acute Respiratory Distress Syndrome Severity Are Correlated With Ventilation-Perfusion Mismatch Measured by Electrical Impedance Tomography. Crit Care Med. 2025 Jan 1;53(1):e42-e53. doi: 10.1097/CCM.0000000000006458. Epub 2024 Oct 24.

  PMID: 39445936 BACKGROUND

• Handel C, Becher T, Miedema M, Kallio M, Papadouri T, Waldmann AD, Sophocleous L, Karaoli C, Yerworth R, Bayford R, Rimensberger PC, van Kaam AH, Frerichs I. Effect of routine suction on lung aeration in critically ill neonates and young infants measured with electrical impedance tomography. Sci Rep. 2023 Nov 27;13(1):20842. doi: 10.1038/s41598-023-42965-7.

  PMID: 38012186 BACKGROUND

• Arriagada R, Bachmann MC, San Martin C, Rauseo M, Battaglini D. Electrical impedance tomography: Usefulness for respiratory physiotherapy in critical illnesses. Med Intensiva (Engl Ed). 2024 Jul;48(7):403-410. doi: 10.1016/j.medine.2024.03.006. Epub 2024 Mar 27.

  PMID: 38538496 BACKGROUND

• Scaramuzzo G, Pavlovsky B, Adler A, Baccinelli W, Bodor DL, Damiani LF, Franchineau G, Francovich J, Frerichs I, Giralt JAS, Grychtol B, He H, Katira BH, Koopman AA, Leonhardt S, Menga LS, Mousa A, Pellegrini M, Piraino T, Priani P, Somhorst P, Spinelli E, Handel C, Suarez-Sipmann F, Wisse JJ, Becher T, Jonkman AH. Electrical impedance tomography monitoring in adult ICU patients: state-of-the-art, recommendations for standardized acquisition, processing, and clinical use, and future directions. Crit Care. 2024 Nov 19;28(1):377. doi: 10.1186/s13054-024-05173-x.

  PMID: 39563476 BACKGROUND

• Xiao L, Yu K, Yang JJ, Liu WT, Liu L, Miao HH, Li TZ. Effect of individualized positive end-expiratory pressure based on electrical impedance tomography guidance on pulmonary ventilation distribution in patients who receive abdominal thermal perfusion chemotherapy. Front Med (Lausanne). 2023 Sep 5;10:1198720. doi: 10.3389/fmed.2023.1198720. eCollection 2023.

  PMID: 37731718 BACKGROUND

• Jiang L, Deng Y, Xu F, Qiao S, Wang C. Individualized PEEP guided by EIT in patients undergoing general anesthesia: A systematic review and meta-analysis. J Clin Anesth. 2024 Jun;94:111397. doi: 10.1016/j.jclinane.2024.111397. Epub 2024 Jan 25.

  PMID: 38278058 BACKGROUND

• Li X, Li M, Zhou J, Feng Y, Zhang K, Xu H, Wang Z, Tian X. EIT Observed Hypoxemia Caused by V/Q Mismatch During One-Lung Ventilation With Indocyanine Green Inhalation: A Report of Two Cases. Respirol Case Rep. 2025 Apr 24;13(4):e70154. doi: 10.1002/rcr2.70154. eCollection 2025 Apr.

  PMID: 40292239 BACKGROUND

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  PMID: 37600211 BACKGROUND

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  PMID: 35116790 BACKGROUND

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  PMID: 28039482 BACKGROUND

MeSH Terms

Conditions

Lung Neoplasms; Hypoxia

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief of Anesthesiology

Study Record Dates

• First Submitted: December 8, 2025
• First Posted: March 27, 2026
• Study Start: July 15, 2025
• Primary Completion: June 30, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: March 27, 2026

Record last verified: 2026-01

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)