Trials Sponsors Conditions Drugs Pricing

Conditions

Alcohol Use Disorder (AUD)Post-Traumatic Stress Disorder, PTSD

Outcome Measures

Primary Outcomes (1)

Regional [18F]PF974 volume of distribution (VT)
proportional to the levels of PDE4B available for radiotracer binding
Once at baseline

Secondary Outcomes (1)

Secondary Region Of Interest (ROI) Binding of [18F]PF974
Once at Baseline

Study Arms (4)

PTSD

Subjects with Post-Traumatic Stress Disorder

Drug: PF974

AUD

Subjects with Alcohol Use Disorder

Drug: PF974

Healthy Controls (HC)

Healthy control subjects without AUD or PTSD/Trauma

Drug: PF974

Trauma Controls (TC)

Trauma Exposed Healthy Controls without AUD or PTSD

Drug: PF974

Interventions

PF974Drug

PF974 Radiotracer.

AUDHealthy Controls (HC)PTSDTrauma Controls (TC)

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 70 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Up to 40 AUD subjects may be enrolled. Up to 40 PTSD subjects may be enrolled. Up to 40 HC subjects may be enrolled. Up to 40 TC subjects may be enrolled.

You may qualify if:

Willing and able to give voluntary written informed consent.

Sponsors & Collaborators

Yale University
Otherlead

Study Sites (1)

Yale University

New Haven, Connecticut, 06510, United States

RECRUITING

Marc GrassoCONTACT2037377074 marc.grasso@yale.edu

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood Samples

MeSH Terms

Conditions

Combat DisordersAlcoholism

Condition Hierarchy (Ancestors)

Stress Disorders, TraumaticTrauma and Stressor Related DisordersMental DisordersAlcohol-Related DisordersSubstance-Related DisordersChemically-Induced Disorders

Study Officials

Kelly Cosgrove, PhD
Yale University
PRINCIPAL INVESTIGATOR

Central Study Contacts

Marc V Grasso

CONTACT

2037377074 marc.grasso@yale.edu

Study Design

Study Type: observational
Observational Model: CASE CONTROL
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

January 29, 2026

First Posted

March 23, 2026

Study Start

July 7, 2025

Actual (reported)

Primary Completion

March 1, 2031

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

You may not qualify if:

Past or current neurological disorder or disorders affecting the brain including but not limited to multiple sclerosis, history of stroke, brain tumors, traumatic brain injury with loss of consciousness, seizure disorder.
Current significant psychiatric disorder including severe substance use disorder (other than alcohol or tobacco use disorders\*) and past or current psychotic symptoms.
Regular use in the past 6 months of any prescription, psychoactive or herbal medications (e.g., antidepressants, antipsychotics, anxiolytics) that would impact the integrity of the data; No subject will be asked to stop taking medication to participate in the study. Participants who are regularly taking P-gp and BCRP inhibitors will be excluded.
Pregnancy or lactation.
Blood donation within eight weeks of the start of the study.
History of a bleeding disorder or are currently taking anticoagulants (such as Coumadin, Heparin, Pradaxa, Xarelto).
Unable to safely discontinue or hold aspirin and other NSAID use.
MRI incompatible implants (i.e., such as pacemaker, artificial joints, non-removable body piercings) and other contraindications for MRI, such as claustrophobia, having implanted or embedded metal objects/fragments or fragments in the head or body that would present a risk during the MRI scanning procedure, or have worked with ferrous metals either as a vocation or hobby (for example, as a sheet metal worker, welder, or machinist).
Participation in other research studies involving ionizing radiation within one year of the PET scans that would cause the subject to exceed the yearly dose limits for healthy volunteers.
Subject who has current, past, or anticipated exposure to radiation in the work place within one year of the proposed research scans that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits.
Has any condition that, in the opinion of the investigator, would prevent compliance with the study protocol.
History of complicated alcohol withdrawal including history of delirium tremens; seizure, hospitalization for withdrawal.
A CIWA score ≥8 at intake or on scan day.
Subjects who are, in the opinion of the study physician, unable to safely abstain from alcohol overnight prior to their study visits.
Subjects with a significant history of repeated alcohol withdrawal, defined as 4 or more medicated detoxifications in the previous 5 years

Imaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (4)

PTSD

AUD

Healthy Controls (HC)

Trauma Controls (TC)

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

Study Start

First Submitted

First Posted

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (1)

Study Arms (4)

PTSD

AUD

Healthy Controls (HC)

Trauma Controls (TC)

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Biospecimen

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations