Intradurale Spinal Tumors: Management and Treatment

NCT07488702 | Active Not Recruiting

• 2 other identifiers: ASO.Nch.25.02Novara Ethical Committee
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Intradurale spinal tumors are rare neoplastic lesions that involve the spinal cord and surrounding structures and may cause neurological symptoms such as pain, motor deficits, sensory disturbances, and sphincter dysfunction. Surgical resection is often the primary treatment when feasible and may improve neurological outcomes and relieve spinal cord compression. This retrospective observational study aims to analyze the epidemiological and clinical characteristics of patients who underwent surgical treatment for intradural spinal tumors at the Neurosurgery Unit of Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria between 2022 and 2024. Clinical, radiological, and pathological data will be collected from electronic medical records, operative reports, and diagnostic imaging. The study will evaluate preoperative and postoperative neurological status using the McCormick functional scale, as well as postoperative complications and tumor recurrence. The results of this study may contribute to improving the understanding of the clinical management of intradural spinal tumors and identifying factors associated with surgical outcomes and patient prognosis.

Conditions

Spinal Cord Neoplasms; Spinal Neoplasms

Keywords

Intradural spinal tumors; Spinal cord neoplasms; Spinal tumor surgery; Neurosurgery; McCormick scale; Neurological outcome; Spinal cord compression; Retrospective study

Outcome Measures

Primary Outcomes (1)

• Neurological Functional Outcome Assessed

  Assessment of neurological functional status in patients undergoing surgical resection of intradural spinal tumors using the McCormick functional grading scale (Grade I: neurologically normal or mild deficit; Grade II: mild functional deficit, independent; Grade III: moderate deficit, limited independence; Grade IV: severe deficit, dependent; Grade V: paraplegia or quadriplegia). Preoperative and postoperative scores will be compared to evaluate changes in neurological function.

  From preoperative assessment to last available follow-up (up to 24 months post-surgery)

Secondary Outcomes (1)

• Postoperative Complications

  From surgery to 30 days postoperatively

Study Arms (1)

Patients With Intradural Spinal Tumors

Patients who underwent surgical treatment for intradural spinal tumors at the Neurosurgery Unit of Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo di Alessandria between 2022 and 2024. Clinical, radiological, and histopathological data were collected retrospectively from medical records to evaluate patient characteristics, neurological outcomes, postoperative complications, and tumor recurrence.

Procedure: Surgical Resection of Intradural Spinal Tumors

Interventions

Surgical Resection of Intradural Spinal Tumors PROCEDURE

This study consists of retrospective data collection and analysis of patients who underwent neurosurgical resection of intradural spinal tumors. No intervention is assigned as part of the study protocol.

Patients With Intradural Spinal Tumors

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent surgical treatment for intradural spinal tumors at the Neurosurgery Unit of Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria between 2022 and 2024. Clinical, radiological, histological, and postoperative outcome data were retrospectively collected from medical records.

You may qualify if:

• Patients hospitalized at Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo di Alessandria (Neurosurgery Unit).
• Patients who underwent surgical resection of an intradural spinal tumor.
• Diagnosis consistent with intradural spinal tumors according to ICD-9 codes.
• Availability of clinical, radiological, and surgical data in medical records.
• Signed informed consent.

You may not qualify if:

• Incomplete medical records or missing clinical data required for the study.
• Tumors with uncertain extradural extension identified during surgery.
• Tumors arising from peripheral nerves.

Sponsors & Collaborators

• Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria: lead

Study Sites (1)

Neurosurgery Unit

Alessandria, Italia, 15121, Italy

Location

MeSH Terms

Conditions

Spinal Cord Neoplasms; Spinal Neoplasms; Spinal Cord Compression

Condition Hierarchy (Ancestors)

Central Nervous System Neoplasms; Nervous System Neoplasms; Neoplasms by Site; Neoplasms; Spinal Cord Diseases; Central Nervous System Diseases; Nervous System Diseases; Bone Neoplasms; Bone Diseases; Musculoskeletal Diseases; Spinal Diseases; Spinal Cord Injuries; Wounds and Injuries

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 18, 2026
• First Posted: March 23, 2026
• Study Start: January 1, 2022
• Primary Completion: December 31, 2024
• Study Completion (Estimated): December 31, 2026
• Last Updated: March 27, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)