Orthostatic And Postprandial Hypotension In Hospitalized Older Adults (HOPE65)

NCT07485998 | Not Yet Recruiting

• 1 other identifier: HOPE65_UKCLJ_2026
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to determine how often orthostatic hypotension and postprandial hypotension occur in adults aged 65 years and older who are hospitalized in internal medicine departments. Orthostatic hypotension is defined as an excessive drop in blood pressure after standing up from a lying or sitting position. Postprandial hypotension is an excessive drop in blood pressure that occurs after eating a meal. These conditions can increase the risk of falls, fainting, loss of independence, and other health problems in older adults. The main questions this study aims to answer are:

• How common orthostatic hypotension and postprandial hypotension are in hospitalized adults aged 65 years and older.
• Whether these conditions are associated with medication use, chronic diseases, and geriatric syndromes (such as frailty, cognitive impairment, and functional decline). Participants will:
• have blood pressure measured while lying down and standing
• have blood pressure measured after a meal
• undergo a comprehensive geriatric assessment, including evaluation of functional status, cognitive function, frailty, mobility, and nutritional status
• provide information about medications and medical history
• be followed for up to 12 months to record outcomes such as falls, syncope, hospitalization, and death

Conditions

Orthostatic Hypotension; Postprandial Hypotension

Keywords

Older Adults; Hospitalized Patients; Blood Pressure Regulation; Falls; Geriatric Syndromes; Comprehensive Geriatric Assessment; Antihypertensive Medication

Outcome Measures

Primary Outcomes (1)

• Prevalence of Orthostatic Hypotension and Postprandial Hypotension in Hospitalized Older Adults at Baseline

  Prevalence of orthostatic hypotension and postprandial hypotension in hospitalized adults aged 65 years and older, assessed using standardized orthostatic blood pressure measurements and postprandial blood pressure measurements. Orthostatic hypotension is defined as a decrease in systolic blood pressure of ≥20 mmHg or diastolic blood pressure of ≥10 mmHg within 3 minutes of standing.

  Baseline (during index hospitalization)

Secondary Outcomes (6)

• Number of Participants with Falls

  12 months

• Number of Participants with Syncope

  12 months

• Number of Participants with Functional Decline

  12 months

• Number of Participants with Hospital Readmission

  12 months

• Number of Participants Who Died from Any Cause

  12 months

Study Arms (1)

Adults aged 65 years and older hospitalized in internal medicine departments at the University Medic

Adults aged 65 years and older hospitalized in internal medicine departments at the University Medical Centre Ljubljana. Participants will undergo orthostatic and postprandial blood pressure measurements and comprehensive geriatric assessment, including evaluation of functional status, cognitive status, frailty, and other geriatric syndromes. Participants will be followed for up to 12 months to assess clinical outcomes.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hospitalized adults aged 65 years and older admitted to internal medicine departments at the University Medical Centre Ljubljana.

You may qualify if:

• Age 65 years or older
• Hospitalization in internal medicine departments at the University Medical Centre Ljubljana
• Duration of hospitalization ≥48 hours
• Hemodynamic stability confirmed by the treating physician
• Ability to participate in study procedures
• Ability to stand (with or without assistive devices for walking)
• Written informed consent obtained

You may not qualify if:

• Medical condition preventing study procedures (e.g., need for continuous supine position)
• Inability to provide informed consent
• Refusal to participate
• Severe cognitive impairment or delirium
• Acute critical illness requiring intensive treatment
• Participation in another clinical study that could affect safety or study outcomes

Sponsors & Collaborators

• University Medical Centre Ljubljana: lead

Study Sites (1)

University Medical Centre Ljubljana

Ljubljana, 1000, Slovenia

Location

MeSH Terms

Conditions

Hypotension, Orthostatic

Condition Hierarchy (Ancestors)

Orthostatic Intolerance; Primary Dysautonomias; Autonomic Nervous System Diseases; Nervous System Diseases; Hypotension; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Amela Kabaklić, MD, PhD

  University Medical Centre Ljubljana

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Amela Kabaklić, MD, PhD

CONTACT

+386 1 522 43 05; amela.kabaklic@kclj.si

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD, Specialist in Internal Medicine

Study Record Dates

• First Submitted: March 12, 2026
• First Posted: March 20, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): April 1, 2030
• Study Completion (Estimated): June 1, 2030
• Last Updated: March 20, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

SL (1)